{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T11:19:09Z","timestamp":1784546349298,"version":"3.55.0"},"reference-count":39,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:00:00Z","timestamp":1760572800000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Acne vulgaris is a chronic inflammatory condition, which is estimated to affect greater than 85% of the population. Acne is a multifactorial condition, which can be influenced by diet, environment, and the microbiome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The purpose of this clinical study is to assess the safety and effects of a prebiotic\u2010containing gel cream on the skin microbiome of individuals with non\u2010cystic acne\u2010prone skin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients\/Methods<\/jats:title>\n                    <jats:p>\n                      In this 7\u2010week clinical trial, 30 eligible participants were recruited and enrolled from the Sacramento region. The study consisted of three visits: (1) screening; (2) week 0, baseline; (3) week 6. All participants received a standard non\u2010comedogenic cleanser and a prebiotic\u2010containing gel cream. The primary endpoint in this study was alteration in\n                      <jats:italic>C<\/jats:italic>\n                      .\n                      <jats:italic>acnes<\/jats:italic>\n                      abundance in mild to moderate non\u2010cystic, acne\u2010prone skin. The secondary endpoint in this study was functional gene analysis for skin barrier and skin inflammation\u2010related genes from whole genome sequencing of the skin microbiome.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Acne lesions significantly reduced in non\u2010inflammatory lesions, inflammatory lesions, and total lesions after treatment (\u221236.0%, \u221234.5%, and \u221235.9%, respectively). On the glabella, there was a 12.5 log2 fold increase in abundance of a healthy strain of\n                      <jats:italic>C. acnes<\/jats:italic>\n                      that is not associated with acne vulgaris. Furthermore, there was a wide range of functional bacterial genetic changes that may be associated with increased collagen and glutathione production. The gel cream was rated very well tolerated, and there were no adverse effects reported.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This prebiotic\u2010containing gel cream can be an effective form of management for acne vulgaris by creating beneficial shifts in the skin microbiome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70138","type":"journal-article","created":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T08:09:38Z","timestamp":1760602178000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Open\u2010Label, Prospective Study of a Prebiotic Gel Cream on Its Efficacy of Mild to Moderate Acne Management and Effects on the Functional Skin Microbiome"],"prefix":"10.1111","volume":"24","author":[{"given":"Laila","family":"Afzal","sequence":"first","affiliation":[{"name":"Integrative Skin Science and Research  Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2045-1819","authenticated-orcid":false,"given":"Ajay S.","family":"Dulai","sequence":"additional","affiliation":[{"name":"Integrative Skin Science and Research  Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zill\u2010e\u2010huma","family":"Khan","sequence":"additional","affiliation":[{"name":"Integrative Skin Science and Research  Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5320-9506","authenticated-orcid":false,"given":"Nhi","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Integrative Skin Science and Research  Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasima","family":"Afzal","sequence":"additional","affiliation":[{"name":"Integrative Skin Science and Research  Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hemali B.","family":"Gunt","sequence":"additional","affiliation":[{"name":"Burt's Bees  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7205-8162","authenticated-orcid":false,"given":"Raja K.","family":"Sivamani","sequence":"additional","affiliation":[{"name":"Integrative Skin Science and Research  Sacramento California USA"},{"name":"Pacific Skin Institute  Sacramento California USA"},{"name":"Department of Dermatology University of California\u2010Davis  Sacramento California USA"},{"name":"College of Medicine California Northstate University  Elk Grove California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,16]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346\u20108138.14586"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrep.2023.101578"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(11)60321\u20108"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu10081049"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms7050128"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.15659.1"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/24.7.1322"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2023.12.017"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.21"},{"issue":"11","key":"e_1_2_11_11_1","first-page":"3","article-title":"Cutibacterium Acnes (Formerly Proprionibacterium Acnes) and Shoulder Surgery","volume":"78","author":"Elston M. 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