{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T12:29:10Z","timestamp":1776774550336,"version":"3.51.2"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T00:00:00Z","timestamp":1743120000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,4]]},"abstract":"ABSTRACT<\/jats:title>Background<\/jats:title>Pulsed\u2010dye lasers (PDLs) are currently regarded as the gold standard for treating port\u2010wine birthmarks (PWBs). Recently, the large\u2010spot, variable\u2010sequenced, long\u2010pulsed potassium titanyl phosphate laser (KTP) has been introduced as a promising alternative for addressing dermatologic vascular lesions. Despite its growing use, data on the efficacy and safety of this technology in treating PWBs over an extended period remain limited.<\/jats:p><\/jats:sec>Aims<\/jats:title>To evaluate the efficacy and safety of a large\u2010spot, variable\u2010sequenced, long\u2010pulsed KTP in the treatment of PWBs over 3\u2009years.<\/jats:p><\/jats:sec>Methods<\/jats:title>A retrospective analysis was conducted on PWB patients treated with the KTP between October 2021 and October 2024. Treatment outcomes were assessed using colorimetric analysis based on the CIE L*a*b* color space system and by measuring the surface area of the lesions. All adverse events (AEs) were documented.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 69 patients were included, with a mean age of 36.5\u2009\u00b1\u200915.6\u2009years. 59.4% were female. Colorimetric analysis revealed an average lightening of PWBs by 75.7%\u2009\u00b1\u200936.1%. Additionally, the surface area of the lesions decreased by 25.3%\u2009\u00b1\u200924.4%. No severe AEs, such as post\u2010inflammatory hyperpigmentation or scarring, were observed.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>This study highlights the potential of large\u2010spot, variable\u2010pulsed KTP as a safe and effective alternative for treating PWBs, demonstrating significant lesion lightening and surface area reduction. With no severe AEs observed, the findings suggest that this technology could complement or serve as an alternative to PDLs. Further prospective studies are warranted to optimize treatment protocols and evaluate long\u2010term outcomes compared to PDL and other vascular treatment options.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.70152","type":"journal-article","created":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T16:51:33Z","timestamp":1743353493000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Treatment of Port\u2010Wine Birthmarks Using a Large\u2010Spot, Variable Sequenced, Long\u2010Pulsed KTP<\/scp>\u2010Laser\u2014A Retrospective Analysis"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1258-6390","authenticated-orcid":false,"given":"Lynhda","family":"Nguyen","sequence":"first","affiliation":[{"name":"Department of Laser and Aesthetics, Department of Dermatology and Venereology University Medical Center Hamburg\u2010Eppendorf Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan W.","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology University Medical Center Hamburg\u2010Eppendorf Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"Herberger","sequence":"additional","affiliation":[{"name":"Department of Laser and Aesthetics, Department of Dermatology and Venereology University Medical Center Hamburg\u2010Eppendorf Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1986.01660140067019"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199103000-00003"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.11.938"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2012.05.027"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-3883"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.10.039"},{"key":"e_1_2_10_8_1","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1111\/ddg.15181","article-title":"Pulsed Dye Laser Treatment of Port\u2010Wine Stains\u2013Analysis of Health Service in Germany","volume":"21","author":"Nguyen L.","year":"2023","journal-title":"Journal der Deutschen Dermatologischen Gesellschaft"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S315804"},{"key":"e_1_2_10_10_1","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1111\/ddg.15612","article-title":"Laser and Light\u2010Based Treatments for Port\u2010Wine Birthmarks\u2013A Systematic Review and Network Meta\u2010Analysis","volume":"23","author":"Nguyen L.","year":"2024","journal-title":"Journal der Deutschen Dermatologischen Gesellschaft"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.1991.tb01597.x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6836297"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2007.01.019"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.1993.tb00353.x"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.19750"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.16300"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2019.11.003"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.11.958"},{"key":"e_1_2_10_19_1","first-page":"27","article-title":"Laser Treatment of Port\u2010Wine Stains","volume":"8","author":"Brightman L. 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