{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:24:03Z","timestamp":1791645843520,"version":"4.3.4"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82373486"],"award-info":[{"award-number":["82373486"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2024JJ9199"],"award-info":[{"award-number":["2024JJ9199"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hemoporfin\u2010mediated photodynamic therapy (HMME\u2010PDT) is a novel and promising treatment for port\u2010wine stains (PWS); however, the factors affecting the efficacy and safety are controversial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>In this study, the relationship between influential factors and the efficacy and safety of HMME\u2010PDT for facial PWS was clarified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this retrospective study, 155 patients suffering from facial PWS who underwent HMME\u2010PDT at 2\u20133\u2009months interval were included. The efficacy was evaluated by the facial PWS area and severity index (FSASI) scoring system based on pre\u2010 and post\u2010treatment photographs of the lesion. The demographic characteristics, lesion patterns, treatment history, number of treatment sessions, and adverse events were also recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After the first and second sessions of HMME\u2010PDT, 61.9% and 92.9% of patients responded, respectively. The lesion subtype, degree of lip involvement, and number of HMME\u2010PDT sessions were associated with the efficacy of HMME\u2010PDT (<jats:italic>p<\/jats:italic>\u2009=\u20090.014, <jats:italic>p<\/jats:italic>\u2009=\u20090.034, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, and respectively). Logistic regression analysis confirmed that the patients with red\u2010type PWS (<jats:italic>p<\/jats:italic>\u2009=\u20090.019) and more HMME\u2010PDT sessions (\u2265\u20092) (<jats:italic>p<\/jats:italic> &lt; 0.001) showed an association with a better response to HMME\u2010PDT. The response rate was higher for lesions on the mandibular prominence area than that on the forehead area (<jats:italic>p<\/jats:italic>\u2009=\u20090.031). No photosensitivity or systemic adverse reactions were reported. Most adverse effects were well tolerated in all patients. Furthermore, the severity of crust was found positively associated with the efficacy (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>HMME\u2010PDT is an effective and safe treatment approach for treating facial PWS. Patients who had red\u2010type, nonforehead area, and more treatment sessions showed an association with better efficacy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.70153","type":"journal-article","created":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T02:47:41Z","timestamp":1743562061000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Influential Factors in the Efficacy and Safety of Hemoporfin\u2010Mediated Photodynamic Therapy for Facial Port\u2010Wine Stains"],"prefix":"10.1111","volume":"24","author":[{"given":"Ruixuan","family":"You","sequence":"first","affiliation":[{"name":"Department of Dermatology The Second Xiangya Hospital of Central South University  Changsha China"},{"name":"Clinical Medical Research Center of Major Skin Diseases and Skin Health of Hunan Province The Second Xiangya Hospital of Central South University  Changsha China"},{"name":"Clinical Medical Research Center for Systemic Autoimmune Diseases in Hunan Province The Second Xiangya Hospital of Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixin","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Second Xiangya Hospital of Central South University  Changsha China"},{"name":"Clinical Medical Research Center of Major Skin Diseases and Skin Health of Hunan Province The Second Xiangya Hospital of Central South University  Changsha China"},{"name":"Clinical Medical Research Center for Systemic Autoimmune Diseases in Hunan Province The Second Xiangya Hospital of Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueqin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Second Xiangya Hospital of Central South University  Changsha China"},{"name":"Clinical Medical Research Center of Major Skin Diseases and Skin 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Second Xiangya Hospital of Central South University  Changsha China"},{"name":"Clinical Medical Research Center of Major Skin Diseases and Skin Health of Hunan Province The Second Xiangya Hospital of Central South University  Changsha China"},{"name":"Clinical Medical Research Center for Systemic Autoimmune Diseases in Hunan Province The Second Xiangya Hospital of Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Second Xiangya Hospital of Central South University  Changsha China"},{"name":"Clinical Medical Research Center of Major Skin Diseases and Skin Health of Hunan Province The Second Xiangya Hospital of Central South University  Changsha China"},{"name":"Clinical Medical Research Center for Systemic Autoimmune Diseases in Hunan Province The Second Xiangya Hospital of Central South University  Changsha 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