{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T14:07:32Z","timestamp":1787580452410,"version":"build-2736575974"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T00:00:00Z","timestamp":1743552000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008040","name":"Kao Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008040","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Although sensitive skin (SS) is a syndrome characterized by cutaneous hypersensitivity to environmental factors, its pathophysiology remains elusive.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>We aimed to explore the characteristics of ceramides (CERs) and intercellular lipid (ICL) structures of individuals with and without facial SS and their relationship with skin hypersensitivity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients\/Methods<\/jats:title>\n                    <jats:p>Healthy Japanese females were divided into SS or non\u2010SS groups based on self\u2010perception and lactic acid stinging test (LAST). Stratum corneum (SC) lipids were analyzed using a liquid chromatograph\u2010mass spectrometer, and the orthorhombic\u2010hexagonal lateral packing structure of ICLs was assessed using electron diffraction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      According to the mean LAST score, individuals with SS (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200948) had mild\u2010to\u2010moderate skin hypersensitivity. SS exhibited not significantly but slightly impaired skin barrier function (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.072) and lower levels of CER[NH], [NP], [EOS], [EOH] (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), and [EOP] (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.073) in the SC compared with non\u2010SS (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200918). Notably, the CER[NP]\/[NS] ratio, a marker of skin barrier function, was positively correlated with the orthorhombic\u2010hexagonal lateral packing ratio of ICLs (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002), whereas it was negatively correlated with the LAST score (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.015) and the interleukin (IL)\u20101 receptor antagonist\/IL\u20101\u03b1 ratio (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003) in the SC, an indicator of chronic inflammation. Moreover, corneocyte size was reduced in SS (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), suggesting inferior SC maturation, and was positively correlated with the CER[NP]\/[NS] (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and the orthorhombic\u2010hexagonal ratios (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.011).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Individuals with SS showed an abnormal CER profile, particularly the altered CER[NP]\/[NS] ratio, which was in turn associated with disordered ICL structure and skin hypersensitivity. Abnormal epidermal turnover may be an underlying mechanism of the abnormalities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70154","type":"journal-article","created":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T14:12:35Z","timestamp":1743775955000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Altered Ceramide Profile of Facial Sensitive Skin: Disordered Intercellular Lipid Structure Is Linked to Skin Hypersensitivity"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-3017-5253","authenticated-orcid":false,"given":"Taisei","family":"Joichi","sequence":"first","affiliation":[{"name":"Skin Care Products Research Kao Corporation  Odawara Kanagawa 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