{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T17:00:30Z","timestamp":1787331630251,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T00:00:00Z","timestamp":1743379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82103705"],"award-info":[{"award-number":["82103705"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Melasma is a common disease that is difficult to treat, with no recognized animal model for mechanism research or drug screening.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To develop a novel, standardized mouse model of melasma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Three different strains of mice (C57BL\/6J, BALB\/c, and KM) were used to create a melasma\u2010like model across various body regions. The skin of the mice was removed on Day 28 and subjected to staining to examine histopathological changes. Data were analyzed using SPSS19.0 software.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared with KM and BALB\/c mice, C57BL\/6J mice were identified as the ideal strain for demonstrating hyperpigmentation more sensitively. The head and ear were identified as more appropriate irradiation sites. Furthermore, a lower irradiation dose was determined to be appropriate for modeling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The C57BL\/6J mouse model more accurately simulates the clinical phenotype of melasma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70155","type":"journal-article","created":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T06:53:09Z","timestamp":1743490389000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A Comparative Study on the Sensitivity of Establishing Melasma\u2010Like Models in Different Strains of Mice"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-0613-5448","authenticated-orcid":false,"given":"Xiaojie","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Laser, Hospital for Skin Diseases, Institute of Dermatology Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenzhu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Laser, Hospital for Skin Diseases, Institute of Dermatology Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hedan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Laser, Hospital for Skin Diseases, Institute of Dermatology Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunyao","family":"Liu","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs Department, Hospital for Skin Diseases, Institute of Dermatology Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Laser, Hospital for Skin Diseases, Institute of Dermatology Chinese Academy of Medical Sciences &amp; 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