{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T13:14:50Z","timestamp":1789391690638,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T00:00:00Z","timestamp":1744675200000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Scant evidence exists for the relative efficacy of therapies for alopecia areata (AA)\u2014including those approved by the Food and Drug Administration, namely, baricitinib, deuruxolitinib, and ritlecitinib.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>We determined the relative efficacy and safety of monotherapy with janus kinase inhibitors (JAKIs), apremilast, and dupilumab.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Following a systematic review, we conducted Bayesian network meta\u2010analysis (NMAs) that produced Surface Under the Cumulative RAnking (SUCRA) values and point estimates for pairwise relative effects; we also performed sensitivity analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, regimens with eight various JAKIs were compared, namely, ruxolitinib, ATI\u2010501, baricitinib, brepocitinib, deuruxolitinib, ivarmacitinib, ritlecitinib, and tofacitinib. Our analyses ranked \u201cdeuruxolitinib 12 mg twice daily for 24\u2009weeks,\u201d the most efficacious insofar as \u201cproportion of participants achieving SALT\u2009\u2264\u200920 at 24\u2009weeks\u201d (SALT<jats:sub>20<\/jats:sub>) (SUCRA\u2009=\u200992.6%), and \u201cproportion of participants achieving SALT\u2009\u2264\u200910 at 24\u2009weeks\u201d (SALT<jats:sub>10<\/jats:sub>) (SUCRA\u2009=\u200997.7%). As per SALT<jats:sub>20<\/jats:sub>, the highest\u2010ranked regimen was more efficacious than \u201cbaricitinib 2 mg once daily for 24\u2009weeks\u201d (odds ratio [OR]\u2009=\u20095.37, 95% credible interval [CI]\u2009=\u20091.59, 13.70, <jats:italic>p\u2009&lt;<\/jats:italic>\u20090.05). Furthermore, the efficacy of the FDA\u2010approved JAKIs exhibited a dose\u2010dependent relationship; for instance, baricitinib 4\u2009mg once daily for 24\u2009weeks was more efficacious than \u201cbaricitinib 2\u2009mg once daily for 24\u2009weeks\u201d in terms of SALT<jats:sub>20<\/jats:sub> (OR\u2009=\u20092.25, 95% CI\u2009=\u20091.56, 3.21, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Results from our sensitivity analyses support that our base analyses were robust.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We produced high\u2010quality evidence on the comparative effectiveness of monotherapies for AA with various regimens of 8 JAKIs, including the FDA\u2010approved ones. Our findings can improve clinicians' decision\u2010making and update guidelines for medical practice.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.70185","type":"journal-article","created":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T09:12:51Z","timestamp":1744708371000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The Relative Efficacy and Safety of Monotherapies for Alopecia Areata: A Network Meta\u2010Analysis Study"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8664-7723","authenticated-orcid":false,"given":"Aditya K.","family":"Gupta","sequence":"first","affiliation":[{"name":"Mediprobe Research Inc.  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London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paradi","family":"Mirmirani","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Permanente Medical Group  Vallejo California USA"},{"name":"Department of Dermatology University of California, San Francisco  San Francisco California USA"},{"name":"Department of Dermatology Case Western Reserve University  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Piguet","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine, Temerty Faculty of Medicine University of Toronto  Toronto Ontario Canada"},{"name":"Division of Dermatology, Women's College Hospital  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0691-640X","authenticated-orcid":false,"given":"Mesbah","family":"Talukder","sequence":"additional","affiliation":[{"name":"School of Pharmacy BRAC University  Dhaka 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