{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T20:06:20Z","timestamp":1781121980358,"version":"3.54.1"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T00:00:00Z","timestamp":1745193600000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p><jats:sub>L\u2010<\/jats:sub>glutamine and linoleic acid (LA) can suppress inflammatory cytokine expression; however, studies on their simultaneous application are limited due to polarity differences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To investigate the effect of glutamine linoleate vesicles (QLAsomes) on skin sensitization by assessing their impact on sensitization\u2010related protein expression, bacterial growth, and clinical efficacy in relieving skin itchiness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>After synthesizing and analyzing QLAsomes, their inhibitory effects on capsaicin\u2010induced cytokine expression and <jats:styled-content style=\"fixed-case\"><jats:italic>Staphylococcus aureus<\/jats:italic><\/jats:styled-content> growth were evaluated. In a double\u2010blind clinical trial, 24 participants (ages 22\u201363) with sensitized skin applied 10\u2009wt% QLAsome cream on one side and a vehicle or no cream on the other twice daily for 2\u2009weeks. Itchiness in the elbow area was assessed using a visual analog scale and expert evaluation. Skin barrier changes were measured using transepidermal water loss (TEWL), skin erythema, and stratum corneum (SC) hydration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>QLAsomes, formed by <jats:sub>L\u2010<\/jats:sub>glutamine and LA through hydrogen bonding, were spherical vesicles (164.6\u2009\u00b1\u20093.1\u2009nm). Based on the inhibitory effects of <jats:sub>L\u2010<\/jats:sub>glutamine and LA on inflammation\u2010related factors, QLAsomes inhibited the capsaicin\u2010induced expression of these factors more effectively than the individual components. IL\u20104 inhibition was improved by over 26%. Matrix metalloproteinase\u20101, which degrades collagen, showed 32% and 23% improvements compared to <jats:sub>L\u2010<\/jats:sub>glutamine and LA, respectively. In a clinical evaluation, 10\u2009wt% QLAsome cream reduced itching by 45% compared to before application, which is a 67% improvement compared to placebo. Skin evaluations revealed improvements in erythema (12%), TEWL (15%), and SC hydration (19%), suggesting that QLAsomes enhance the skin barrier function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>QLAsomes showed up to 32% higher expression inhibition of key skin sensitization\u2010related factors than individual components, and based on this, improved pruritus by 67% more than placebo. As nanovesicles with skin\u2010soothing properties, they are effective for drug encapsulation and managing skin sensitivity in pharmaceutical and cosmetic industries.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.70195","type":"journal-article","created":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T01:40:34Z","timestamp":1745286034000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Nanovesicles for Sensitive Skin Care Developed via Self\u2010Assembly of Glutamine Linoleate"],"prefix":"10.1111","volume":"24","author":[{"given":"Koo Chul","family":"Kwon","sequence":"first","affiliation":[{"name":"SEORIN COMPANY Co., Roundlab R&amp;D Center  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi Jung","family":"Kim","sequence":"additional","affiliation":[{"name":"SEORIN COMPANY Co., Roundlab R&amp;D Center  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang A.","family":"Yoon","sequence":"additional","affiliation":[{"name":"SEORIN COMPANY Co., Roundlab R&amp;D Center  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13532"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2494.2012.00754.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1586\/17469872.2013.856688"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1037925"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.870952"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14464"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules18010322"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms252111598"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2009.06920.x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2003000200002"},{"key":"e_1_2_10_12_1","first-page":"8","article-title":"TRPV1 Antagonist Can Suppress the Atopic Dermatitis\u2010Like Symptoms by Accelerating Skin Barrier Recovery","volume":"62","author":"Yun J. 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