{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T22:12:28Z","timestamp":1788300748364,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T00:00:00Z","timestamp":1752451200000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hybrid cooperative complex hyaluronic acid (HCC HA) is a novel, widely used injectable developed using the patented NAHYCO Hybrid Technology for the treatment of the face and body, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To examine the safety profile of HCC HA from global post\u2010marketing surveillance data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Post\u2010marketing adverse events (AEs) reported for HCC HA injected to the face (Profhilo, HCC\u2010HA<jats:sub>PROF<\/jats:sub>, IBSA Farmaceutici Italia Srl, Italy) from January 1, 2018 to October 31, 2023 and to the body (Profhilo Body, HCC\u2010HA<jats:sub>PROF\u2010B<\/jats:sub>, IBSA Farmaceutici Italia Srl, Italy) from January 1, 2020 to October 31, 2023 were analyzed. Patient exposure and the proportion of exposed patients with a safety complaint were also estimated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The total number of patients exposed to HCC\u2010HA<jats:sub>PROF<\/jats:sub> and HCC\u2010HA<jats:sub>PROF\u2010B<\/jats:sub> globally was projected to be 1\u2009091\u2009956 and 27\u2009692, respectively. There was a total of 371 AEs recorded for HCC\u2010HA<jats:sub>PROF<\/jats:sub>, and 11 AEs reported for HCC\u2010HA<jats:sub>PROF\u2010B<\/jats:sub>, corresponding to 0.034% and 0.040% of the patients, respectively. The most common AEs were edema, erythema, and discomfort, which are consistent with the manner and location of administration, and the AEs are frequently reported following treatment. The proportion of exposed patients with a safety complaint was low, with 0.026%\u20130.050% and 0%\u20130.013% of patients exposed to HCC\u2010HA<jats:sub>PROF<\/jats:sub> or HCC\u2010HA<jats:sub>PROF\u2010B<\/jats:sub> experiencing a safety complaint, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Post\u2010marketing surveillance indicated favorable safety profiles for HCC\u2010HA<jats:sub>PROF<\/jats:sub> and HCC\u2010HA<jats:sub>PROF\u2010<\/jats:sub>, with the most common AEs expected and\/or related to the method or site of administration.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.70197","type":"journal-article","created":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T09:10:46Z","timestamp":1752484246000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Hyaluronic Acid Hybrid Cooperative Complexes Nearing 10\u2009Years of Use: Update on Safety Assessment Based on Post\u2010Marketing Surveillance Data"],"prefix":"10.1111","volume":"24","author":[{"given":"Giovanni","family":"Salti","sequence":"first","affiliation":[{"name":"Medlight Institute  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonello","family":"Tateo","sequence":"additional","affiliation":[{"name":"Private Practice  Milan and Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Cassuto","sequence":"additional","affiliation":[{"name":"Private Practice  Israel"},{"name":"Private Practice  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Arrigoni","sequence":"additional","affiliation":[{"name":"Agor\u00e0 Clinical Educational Centre  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Godina","sequence":"additional","affiliation":[{"name":"IBSA Institut Biochimique SA  Lugano Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Mazzola","sequence":"additional","affiliation":[{"name":"IBSA Institut Biochimique SA  Lugano Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5893-4784","authenticated-orcid":false,"given":"Clara","family":"Cigni","sequence":"additional","affiliation":[{"name":"IBSA Farmaceutici Italia Srl  Lodi Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Grimolizzi","sequence":"additional","affiliation":[{"name":"IBSA Farmaceutici Italia Srl  Lodi Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilberto","family":"Bellia","sequence":"additional","affiliation":[{"name":"IBSA Farmaceutici Italia Srl  Lodi 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