{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T19:08:56Z","timestamp":1785438536579,"version":"3.56.0"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:00:00Z","timestamp":1745452800000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Acne often leads to enlarged pores on the facial skin, seriously affecting the patient's appearance. Topical and oral medications have poor efficacy in some cases of severe pore enlargement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to explore the clinical efficacy and safety of botulinum toxin A combined with hyaluronic acid in improving facial pore enlargement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A retrospective study was conducted on 40 acne patients with enlarged pores. Botulinum toxin A and non\u2010cross\u2010linked hyaluronic acid compound were injected into the patient's face using mesotherapy with nine 32\u2010gauge microneedles. VISIA was used to record the conditions of facial pores, texture, and porphyrins. The physician's assessment of the improvement score and the patient satisfaction evaluation are used to evaluate the treatment effect.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>One month after treatment, the combination of botulinum toxin and non\u2010cross\u2010linked hyaluronic acid compound significantly improved facial pore enlargement. Although the effects decreased, the conditions of facial pores, texture, and porphyrins 4\u2009months after treatment still had a significant difference from those at baseline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The combination of botulinum toxin A and non\u2010cross\u2010linked hyaluronic acid compound is safe and effective in treating enlarged pores, indicating its promotional value.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.70198","type":"journal-article","created":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T07:24:31Z","timestamp":1745479471000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Combination of Botulinum Toxin A and Hyaluronic Acid Improved Facial Pore Enlargement Caused by Acne"],"prefix":"10.1111","volume":"24","author":[{"given":"Rongli","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Dermatology The First Affiliated Hospital of Xi'an Jiaotong University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyang","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Dermatology The First Affiliated Hospital of Xi'an Jiaotong University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Weinan Central Hospital  Weinan Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jintian","family":"Luo","sequence":"additional","affiliation":[{"name":"Zhongshan School of Medicine, Sun Yat\u2010Sen University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajie","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Dermatology The First Affiliated Hospital of Xi'an Jiaotong University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoli","family":"Cheng","sequence":"additional","affiliation":[{"name":"Basic Medical Experiment Teaching Center Health Science Center, Xi'an Jiaotong University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muyan","family":"Zou","sequence":"additional","affiliation":[{"name":"Medical Department Imeik Technology Development Co., Ltd.  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