{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T11:08:52Z","timestamp":1781608132569,"version":"3.54.5"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:00:00Z","timestamp":1747180800000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Skin radiance represents both healthy and esthetic aspects of human skin, usually influenced by a compromised barrier and the aging process. The reduction of the stratum corneum by chemical peels is a prevalent procedure employed to enhance facial radiance, but peeling is not suitable for compromised skin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Prinsepia utilis Royle<\/jats:italic>\n                      polysaccharides (PURP) is a natural extract with repairing properties, which has been reported as a barrier repairing agent. ESETRILLQ (EQ) peptide has been recently reported as a novel antiaging bioactive peptide. This study aims to investigate the combined efficacy of these two ingredients on skin radiance enhancement.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Reconstructed human full\u2010thickness skin models were subjected to UVA exposure, followed by treatment with 1000\u2009ppm PURP, 20\u2009ppm EQ9, and their combinations: PUR9\u20101 (1000\u2009ppm PURP + 10\u2009ppm EQ9) and PUR9\u20102 (1000\u2009ppm PURP + 20\u2009ppm EQ9). Transcriptomic profiling was performed as a preliminary study to define the synergistic effect. RT\u2010qPCR was performed assessing the regulation of skin barrier\u2010related genes. Thirty\u2010three Chinese sensitive skin individuals were enrolled in a placebo\u2010controlled split\u2010face clinical research for 2\u2009weeks to evaluate a PUR9\u20102 containing lotion. Instrument measurement and expert evaluation were conducted to evaluate the parameters of glossiness and skin tone at baseline, Day 7, and Day 14. Skin glossiness was determined by VISIA 7, Glossymeter, and Translucency Meter. TEWL was determined by Tewameter Hex. Wrinkel number and area were obtained by VISIA 7.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Transcriptomic profiling identified PUR9\u20102 to regulate significantly different genes distinct from PURP and EQ9. The combination increased the gene expression levels of TNFAIP3 and CRNN. PUR9\u20102 also increased the expression of FLG, LOR, and DSG1on UVA\u2010irradiated skin model. PUR9\u20102 containing lotion significantly decreased TEWL by 16.96%. Clinical evaluations demonstrated a statistically significant 22.32% (Glossymeter) and 35.56% (VISIA 7) improvement in skin glossiness on the PUR9\u20102 lotion\u2010treated side by Day 14 compared to baseline. Translucency demonstrated a statistically significant 13.06% increase of\n                      <jats:italic>K<\/jats:italic>\n                      value, which all aligned with the expert evaluation of skin radiance enhancement.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PCA analysis revealed PUR9\u20102 uniquely modulated gene expression compared to PURP and EQ9. Functional enrichment analysis based on Gene Ontology (GO) demonstrated PUR9\u20102 restored UVA\u2010suppressed TNFAIP3 and CRNN gene. The results of RT\u2013PCR also indicated that PUR9\u20102 enhanced skin barrier integrity in 3D models via upregulated expression of FLG, LOR, and DSG1. The Chou\u2010Talalay method further validated PUR9\u20102's synergistic potency (CI &lt;\u20091) in accelerating keratinocyte scratch wound closure. The clinical research demonstrated protective effects of PUR9\u20102 on compromised skin barrier and enhanced both glossiness of the sensitive skin surface and translucency within the skin structure. This study provides a potential solution for improving the radiance and overall conditions of compromised skin.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70204","type":"journal-article","created":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T13:44:26Z","timestamp":1747230266000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Synergistic Enhancement of Compromised Skin Radiance: A Clinical Investigation of\n                    <i>Prinsepia utilis Royle<\/i>\n                    Polysaccharides and Nonapeptide Co\u2010Application"],"prefix":"10.1111","volume":"24","author":[{"given":"Chong","family":"Qin","sequence":"first","affiliation":[{"name":"Yunnan Characteristic Plant Extraction Laboratory Yunnan Yunke Characteristic Plant Extraction Laboratory Co., Ltd.  Kunming Yunnan China"},{"name":"Shanghai Jiyan Biomedical Development Co., Ltd.  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