{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T04:47:03Z","timestamp":1793249223623,"version":"4.5.0"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,25]],"date-time":"2025-05-25T00:00:00Z","timestamp":1748131200000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Exosomes, an emerging treatment of interest to aesthetic dermatology, have therapeutic applications in skin rejuvenation, alopecia, atopic dermatitis, acne scarring, and wound healing. Platelet\u2010rich plasma has been widely utilized for the same indications, among others. Currently, there are no trials comparing the two regenerative modalities in aesthetic dermatology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To compare the efficacy and safety of adipose mesenchymal stem cell\u2010derived (ASC) exosomes versus platelet\u2010rich plasma for photoaged facial skin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>An investigator\u2010blinded, split\u2010face trial was conducted. Participants with mild to moderate photoaging underwent three radiofrequency microneedling treatments with PRP and topical exosomes each applied to one half of the face.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Both exosomes and PRP equally improved wrinkling, dyschromia, erythema, texture, and overall skin appearance. Histological analysis confirmed increased collagen I and glycosaminoglycans, without significant differences between treatment arms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>ASC exosomes are a promising PRP\u2010alternative that may be attractive to needle\u2010averse patients and can hasten the office visit duration, as phlebotomy and centrifugation are not required.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70208","type":"journal-article","created":{"date-parts":[[2025,5,25]],"date-time":"2025-05-25T22:10:28Z","timestamp":1748211028000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Adipose Mesenchymal Stem Cell\u2010Derived Exosomes Versus Platelet\u2010Rich Plasma Treatment for Photoaged Facial Skin: An Investigator\u2010Blinded, Split\u2010Face, Non\u2010Inferiority Trial"],"prefix":"10.1111","volume":"24","author":[{"given":"Blanca","family":"Estupi\u00f1an","sequence":"first","affiliation":[{"name":"Skin Laser &amp; Surgery Specialists, a Division of Schweiger Dermatology Group  Hackensack New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Ly","sequence":"additional","affiliation":[{"name":"Skin Laser &amp; Surgery Specialists, a Division of Schweiger Dermatology Group  Hackensack New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8950-439X","authenticated-orcid":false,"given":"David J.","family":"Goldberg","sequence":"additional","affiliation":[{"name":"Skin Laser &amp; Surgery Specialists, a Division of Schweiger Dermatology Group  Hackensack New Jersey USA"},{"name":"Department of Dermatology Icahn School of Medicine at Mt. 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