{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T03:10:27Z","timestamp":1783653027691,"version":"3.55.0"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T00:00:00Z","timestamp":1745971200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T00:00:00Z","timestamp":1745971200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Rosacea is a chronic inflammatory skin disease, commonly affecting the central part of the face, characterized by erythema, flushing, telangiectasias, papules, and pustules. It may also involve sensations of burning, tingling, and occasionally fibrous changes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This study aims to compare the efficacy, side effect profiles, and patient satisfaction of topical 20% azelaic acid and 7.5% dapsone in the treatment of mild\u2010to\u2010moderate papulopustular rosacea (Stage 2).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Ethics approval was obtained. A retrospective analysis was conducted on the medical records of 76 patients, including 44 in the azelaic acid group and 32 in the dapsone group, all diagnosed with mild\u2010to\u2010moderate papulopustular rosacea. These patients were treated with either topical azelaic acid or dapsone at the dermatology outpatient clinic between August 1, 2022 and December 31, 2022. Demographic characteristics, Investigator's Global Assessment scores, lesion counts, erythema scores, side effects, and patient satisfaction data were analyzed in the study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      No statistically significant differences were found between groups based on pretreatment IGA values, separate IGA scores (2\u20134), lesion counts, average erythema scores, or separate erythema scores (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05 for all). Within each group, comparisons of pre\u2010 and posttreatment IGA values, lesion counts, and erythema scores revealed statistically significant differences (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001 for all), indicating that both treatments were effective. When comparing the groups based on posttreatment IGA values, separate IGA scores (0\u20133), improvement percentages in IGA values, lesion counts, improvement percentages in lesion counts, average erythema scores, separate erythema scores (0\u20132), and improvement percentages in erythema scores, no significant differences were observed (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05 for all).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Topical dapsone is as effective as azelaic acid in treating mild\u2010to\u2010moderate papulopustular rosacea and is associated with fewer side effects, making it a safer option.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70212","type":"journal-article","created":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T07:25:22Z","timestamp":1745997922000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Comparison of Topical 20% Azelaic Acid and 7.5% Dapsone in the Treatment of Mild\u2010To\u2010Moderate Papulopustular Rosacea"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8774-3362","authenticated-orcid":false,"given":"Sabir","family":"Hasanbeyzade","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Dr. R\u0131dvan Ege Research and Practice Hospital Ufuk University  Ankara T\u00fcrkiye"},{"name":"Dermatology and Venerology Department Hitit University Erol Olcok Training and Research Hospital  Corum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.120625"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0095-4543(05)70197-4"},{"key":"e_1_2_9_4_1","first-page":"214","article-title":"Diagnosis and Treatment of Rosacea","volume":"15","author":"Cohen A. F.","year":"2002","journal-title":"Journal of the American Board of Family Practice"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.03.030"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1994.01690030091015"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02850193"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-9740.2003.01876.x"},{"issue":"3","key":"e_1_2_9_9_1","first-page":"17","article-title":"Reactive Oxygen Species and Rosacea","volume":"74","author":"Jones D.","year":"2004","journal-title":"Cutis"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.139.11.1444"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(85)90630-6"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12277084"},{"key":"e_1_2_9_13_1","first-page":"19","article-title":"Azelaic Acid in Rosacea?","volume":"126","author":"Nazzaro\u2010Porro M.","year":"1991","journal-title":"Giornale Italiano di Dermatologia e Venereologia"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/10715769109049121"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00372056"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1529-8019.2002.01543.x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-013-1409-7"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2001.01503.x"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00915288"},{"issue":"6","key":"e_1_2_9_20_1","first-page":"602","article-title":"Dapsone Gel in the Treatment of Papulopustular Rosacea: A Double\u2010Blind Randomized Clinical Trial","volume":"14","author":"Faghihi G.","year":"2015","journal-title":"Journal of Drugs in Dermatology"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3109\/09546639309082150"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/000155599750009906"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(99)70085-X"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/15569527.2024.2424932"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70212","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.70212","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70212","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T03:29:02Z","timestamp":1773718142000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.70212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,30]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1111\/jocd.70212"],"URL":"https:\/\/doi.org\/10.1111\/jocd.70212","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,30]]},"assertion":[{"value":"2025-02-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70212"}}