{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T22:41:53Z","timestamp":1792104113242,"version":"4.4.0"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T00:00:00Z","timestamp":1747872000000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100016262","name":"PharmaResearch Products","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016262","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Dry and chapped lips are a common nuisance. Besides the discomfort, many report feeling embarrassed over the unsightly appearance of their chapped lips. The aim of this study was to determine if polynucleotide (PN) injection helps relieve lip dryness and assess safety in practicing PN in this specific area.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this prospective study, 30 Korean subjects with dry and chapped lips enrolled to receive PN injection on the vermilion zone (a total of 3 injections, each 3\u2009weeks apart). Vermilion wrinkle and roughness were scored based on the photos taken pretreatment (week 0); before the 2nd and 3rd injection (week 3, week 6); and 3\u2009weeks after the 3rd injection (week 9) using the respective severity rating scales. Safety data were obtained throughout the study period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 27 individuals completed the study. PN significantly improved both the vermilion wrinkles (assessed by the Wrinkle Severity Rating Scale (WSRS)) and roughness (assessed by the Lip Roughness Grading Scale (LRGS)) at all time points compared to baseline (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). The WSRS response rate (Ratio of subjects whose WRSR decreased by \u2265\u20091 point compared to baseline) at week 9 was 100%. Lip swelling was experienced by all subjects when examined 30\u2009min after PN injection, followed by pain (90%) and redness (77%). The injection site adverse reactions were mostly mild and transient.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our results suggest that PN may be a promising option to soothe dry and chapped lips. However, larger studies with long\u2010term follow\u2010up are necessary to confirm the preliminary findings of this study.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70224","type":"journal-article","created":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T13:07:53Z","timestamp":1747919273000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Clinical Efficacy and Safety of a Highly Purified Polynucleotide for Dry and Chapped Lips: A Prospective, Multicenter Study"],"prefix":"10.1111","volume":"24","author":[{"given":"Nark Kyung","family":"Rho","sequence":"first","affiliation":[{"name":"Leaders Aesthetic Laser and Cosmetic Surgery Center  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Jun","family":"Park","sequence":"additional","affiliation":[{"name":"Maylin Clinic Cheongdam  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0576-0474","authenticated-orcid":false,"given":"Hei Sung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Incheon St. Mary's Hospital College of Medicine, The Catholic University of Korea  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.16317"},{"issue":"2","key":"e_1_2_7_3_1","first-page":"116","article-title":"The Lips: Anatomy and Differential Diagnosis","volume":"38","author":"Zugerman C.","year":"1986","journal-title":"Cutis"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004030050453"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102133.2003.05741.x"},{"issue":"12","key":"e_1_2_7_6_1","first-page":"44","article-title":"Clinical Assessment of a Combination Lip Treatment to Restore Moisturization and Fullness","volume":"2","author":"Trookman N. S.","year":"2009","journal-title":"Journal of Clinical and Aesthetic Dermatology"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ics.12692"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ics.12677"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/ics.12583"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.13627"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12299"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2020.1748857"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13679"},{"key":"e_1_2_7_14_1","first-page":"27","article-title":"Long Chain Polynucleotides Gel and Skin Biorevitalization","volume":"3","author":"Cavallini M.","year":"2007","journal-title":"Journal of Plastic Dermatology"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100846.2005.00115.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.2147\/ccid.S179430"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13871"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25158224"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.16125"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-0844(199906)17:2<107::AID-CBF815>3.0.CO;2-#"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0024\u20103205(99)00104\u20106"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13199"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/ics.12335"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467\u20102494.2004.00217_01.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.12456"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.23812\/20\u2010320\u2010l"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fsurg.2021.681028"},{"issue":"1","key":"e_1_2_7_28_1","first-page":"28","article-title":"Effect of Race on Lower Lip Hydration","volume":"17","author":"Gunt H. B.","year":"2024","journal-title":"Journal of Clinical and Aesthetic Dermatology"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.2147\/ccid.S417214"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266\u2010021\u201002190\u2010x"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjw168"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1177\/1090820x10374095"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70224","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.70224","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70224","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T03:31:32Z","timestamp":1773718292000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.70224"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1111\/jocd.70224"],"URL":"https:\/\/doi.org\/10.1111\/jocd.70224","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"2024-09-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70224"}}