{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:03:27Z","timestamp":1791407007593,"version":"4.3.3"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,25]],"date-time":"2025-05-25T00:00:00Z","timestamp":1748131200000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Facial erythema and acne scarring are common skin conditions that significantly impair quality of life, necessitating effective treatment options, particularly in Asian populations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To evaluate the efficacy and safety of intradermal injections of recombinant type III humanized collagen (RhCol\u2010III) solution for alleviating facial erythema, improving skin texture associated with acne scarring, and evening out skin tone issues associated with post\u2010inflammatory hyperpigmentation (PIH) from acne while also searching for potential underlying anti\u2010inflammatory mechanisms of the RhCol\u2010III solution.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This case series included six Chinese participants with Fitzpatrick phototypes III\/IV, presenting with facial erythema and\/or acne scarring. Participants received intradermal injections of 2\u2009mg\/mL RhCol\u2010III solution at baseline, 30\u2010 and 60\u2010 days post\u2010baseline. Clinical evaluations were conducted using VISIA photography and self\u2010assessed Global Aesthetic Improvement Scale (GAIS) scores. Additionally, in\u00a0vitro testing was performed using the U937 cell line with lipopolysaccharide (LPS) induction to assess the anti\u2010inflammatory effects of the RhCol\u2010III solution on tumor necrosis factor\u2010alpha (TNF\u2010\u03b1) and interleukin\u20106 (IL\u20106) secretion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>All participants demonstrated a reduction in facial erythema post\u2010treatment, with significant improvements noted in the zygomatic area. The mean erythema area decreased by 49.3% after 90\u2009days. One case with acne scarring showed visible improvement in scar appearance, skin tone, and texture. Moreover, 0.10\u2009mg\/mL RhCol\u2010III solution significantly reduced TNF\u2010\u03b1 and IL\u20106 levels in\u00a0vitro by up to 47.75% and 44.96%, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>RhCol\u2010III solution injections effectively reduced facial erythema and have the potential to improve acne scarring via reduction in the extent of PIH in this series of Chinese cases. The treatment was well\u2010tolerated, with no significant adverse effects. These findings suggest RhCol\u2010III solution as a promising therapeutic option for skin repair and inflammation reduction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70226","type":"journal-article","created":{"date-parts":[[2025,5,25]],"date-time":"2025-05-25T22:15:12Z","timestamp":1748211312000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Recombinant Type\n                    <scp>III<\/scp>\n                    Humanized Collagen Solution for Injection Promotes Skin Repair in Chinese Population: A Case Series"],"prefix":"10.1111","volume":"24","author":[{"given":"Xiaoguang","family":"Duan","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery Chingho Medical Center  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunmei","family":"Ding","sequence":"additional","affiliation":[{"name":"L'Or\u00e9al Research &amp; Innovation China Advanced Research  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiewei","family":"Wu","sequence":"additional","affiliation":[{"name":"L'Or\u00e9al Dermatological Beauty China Skinceuticals  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Bao","sequence":"additional","affiliation":[{"name":"L'Or\u00e9al Dermatological Beauty China Skinceuticals  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Gao","sequence":"additional","affiliation":[{"name":"L'Or\u00e9al Research &amp; Innovation China Advanced Research  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Liu","sequence":"additional","affiliation":[{"name":"L'Or\u00e9al Dermatological Beauty China Skinceuticals  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery The Second Affiliated Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,25]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.1913.sp000144"},{"key":"e_1_2_11_3_1","first-page":"139","article-title":"Vascular Reactions of the Skin to Injury, Part X\u2014The Intervention of a Chemical Stimulus Illustrated Especially by the Flare. The Response to Faradism","volume":"14","author":"Lewis T.","year":"1927","journal-title":"Heart"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100846.2007.00238.x"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2pp25152c"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S267203"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ina.12918"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555\u2010015\u20100077\u20102"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.2165\/00128071\u2010200910030\u201000002"},{"issue":"9","key":"e_1_2_11_10_1","first-page":"12","article-title":"Acne Scarring\u2010Pathogenesis, Evaluation, and Treatment Options","volume":"10","author":"Connolly D.","year":"2017","journal-title":"Journal of Clinical and Aesthetic Dermatology"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S406235"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S350040"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.15584"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2018.09.188"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2021.10.004"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.1671\u20100290.2022.04.012"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.12440"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.13060"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2018.12.018"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s42825\u2010022\u201000103\u20105"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21249739"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v12.i16.2713"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14234975"},{"key":"e_1_2_11_24_1","first-page":"101","article-title":"The Role of IL\u20106 in Skin Fibrosis and Cutaneous Wound Healing","volume":"8","author":"Johnson B. 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