{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:21:10Z","timestamp":1792027270294,"version":"4.4.0"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["2023\u2010SB\u2010SB\u20100015"],"award-info":[{"award-number":["2023\u2010SB\u2010SB\u20100015"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The accumulation of advanced glycation end products (AGEs) in aged skin and their pro\u2010aging effects suggest the potential application of anti\u2010glycation ingredients as skin anti\u2010aging agents.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study evaluated the anti\u2010aging efficacy of a newly developed anti\u2010glycation ingredient with antioxidant and autophagy\u2010stimulating activities through in\u00a0vitro, ex\u00a0vivo, and clinical efficacy tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      AGEs formation in both the cell\u2010free BSA\/glyoxal system and glucose\/glyoxal\u2010treated human epidermal keratinocytes was measured, while the degradation of pre\u2010formed BSA\/AGEs by keratinocytes was assessed. Anti\u2010glycation and anti\u2010inflammatory effects were further examined using\n                      <jats:italic>an<\/jats:italic>\n                      ex\u00a0vivo human skin explant model. Clinical anti\u2010aging effects were analyzed by assessing skin AGE levels, melanin and erythema indices, skin elasticity, and skin hydration levels.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The tested ingredient inhibited AGE formation and accelerated the degradation of pre\u2010formed AGEs in\u00a0vitro. A significant reduction in skin AGE levels, reduction of skin melanin and erythema indices, and improvement of skin elasticity and hydration in healthy volunteers were observed after 2 and 4\u2009weeks of test product application.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A newly synthesized antioxidant with autophagy\u2010stimulating activity exhibited significant anti\u2010glycation efficacy in both in\u00a0vitro and clinical studies, suggesting its potential as an effective skin anti\u2010aging ingredient.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70240","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T08:48:38Z","timestamp":1747644518000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Anti\u2010Glycation and Anti\u2010Aging Efficacy of Newly Synthesized Antioxidant With Autophagy Stimulating Activity"],"prefix":"10.1111","volume":"24","author":[{"given":"Kayoung","family":"Shin","sequence":"first","affiliation":[{"name":"Research Team Incospharm Corp  Daejeon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeonjae","family":"Kim","sequence":"additional","affiliation":[{"name":"Research Team Incospharm Corp  Daejeon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sungwoo","family":"Kim","sequence":"additional","affiliation":[{"name":"Research Team Incospharm Corp  Daejeon South Korea"},{"name":"Department of Dermatology Chungnam National University Sejong Hospital  Sejong South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun","family":"Jung Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology Chungnam National University Sejong Hospital  Sejong South 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