{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T05:07:43Z","timestamp":1773724063750,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Androgenetic alopecia (AGA) is a common age\u2010related hair loss condition influenced by genetics and androgen activity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This study evaluated the safety and efficacy of Cuticapil Stem Hair Serum in improving hair loss in AGA patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>This multicenter, prospective, observational study assessed the real\u2010world efficacy and safety of Cuticapil Stem Hair Serum in patients with androgenetic alopecia. A total of 60 subjects were evaluated, with the Cuticapil and Standard of Care groups compared using the Mann\u2013Whitney and Wilcoxon signed\u2010rank tests. Key assessments included the hair pull test, global photographic analysis, and hair shedding count. No adverse events were reported, reinforcing the serum's favorable safety profile.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>\n                      The Cuticapil + SoC treatment group consistently showed higher mean ranks across multiple parameters compared to the SoC\u2010only group. The addition of Cuticapil Serum to SoC significantly reduced hair shedding (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0220). In the Hair Pull Test, the Cuticapil + SoC group had a lower mean rank (26.97) than SoC alone (34.03) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0196), indicating greater efficacy. Global photography analysis showed a higher mean rank of 36.13 in the Cuticapil + SoC group compared to 24.87 in the SoC group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0057), further supporting its effectiveness.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Cuticapil Stem Hair Serum, when used in addition to standard care, significantly enhances hair growth and reduces hair fall in patients with mild to moderate Androgenetic Alopecia and Female Pattern Hair Loss. It showed superior results in promoting hair growth, reducing shedding, improving hair density, appearance, and managing hair loss.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70247","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T06:09:52Z","timestamp":1747634992000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Real\u2010World Efficacy and Safety of Cuticapil Stem Hair Serum as an Add\u2010On to Minoxidil in Androgenetic Alopecia: A Prospective Observational Study"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1914-8043","authenticated-orcid":false,"given":"Rachita","family":"Dhurat","sequence":"first","affiliation":[{"name":"RD Clinic  Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9507-0217","authenticated-orcid":false,"given":"Girish R.","family":"Kulkarni","sequence":"additional","affiliation":[{"name":"Torrent Pharmaceuticals Ltd  Ahmedabad India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anil","family":"Ganjoo","sequence":"additional","affiliation":[{"name":"Dr. Ganjoo's Skin and Cosmetology Centre  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manjul","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Mira Derm Redefining Skin Care  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pradeep","family":"Kumari","sequence":"additional","affiliation":[{"name":"Asia Institute of Hair Transplant  Pune India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pradyuman","family":"Vaidya","sequence":"additional","affiliation":[{"name":"Dr. Vaidys's Skin and Laser Clinic  Pune India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumit","family":"Gupta","sequence":"additional","affiliation":[{"name":"GNH Excel Medical Centre  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shankar","family":"Savant","sequence":"additional","affiliation":[{"name":"Rejoice Aesthetic Experts  Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rathish","family":"Nair","sequence":"additional","affiliation":[{"name":"Torrent Pharmaceuticals Ltd  Ahmedabad India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahima","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Mira Derm Redefining Skin Care  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pankhuri","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Parmarth Mission Hospital  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,19]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"22","article-title":"Epidemiology and Treatment Aspects of Hair Loss in India\u2013A Cross\u2010Sectional, Multicentre, Database Study (HAILO)","volume":"6","author":"Gala M.","year":"2023","journal-title":"Asian Journal of Research in Dermatological Science"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14537"},{"key":"e_1_2_11_4_1","first-page":"249","article-title":"Classification of the Types of Androgenetic Alopecia (Common Baldness) Arising in the Female Sex","volume":"97","author":"Ludwig E.","year":"1997","journal-title":"British Journal of Dermatology"},{"key":"e_1_2_11_5_1","first-page":"371","article-title":"Hair Loss: Common Causes and Treatment","volume":"96","author":"Phillips T. G.","year":"2017","journal-title":"American Family Physician"},{"key":"e_1_2_11_6_1","first-page":"929","article-title":"A Prospective, Randomized Double\u2010Blind, Placebo\u2010Controlled Study for Safety and Efficacy of SesZen\u2010BioTM: A Proprietary Sesbania Grandiflora Extract in Managing Hair and Scalp Health in Healthy Adults","volume":"11","author":"Gadani M. C.","year":"2024","journal-title":"International Journal of Clinical Trials"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20175241"},{"issue":"5","key":"e_1_2_11_8_1","article-title":"Prospective Efficacy and Safety Study of an Innovative Kerascalp Hair Growth Serum in Mild\u2010To\u2010Moderate Alopecia in India: Regrowth Study","volume":"15","author":"Kohli M.","year":"2023","journal-title":"Cureus"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijwd.2018.05.001"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.116732"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000063908"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/09546630903578574"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19030691"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/cosmetics8010025"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.119104"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.7861\/clinmedicine.16-1-74"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000492035"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/cosmetics11050149"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S334145"},{"key":"e_1_2_11_20_1","article-title":"A Comparative Study of Topical Procapil With Platelet\u2010Rich Plasma Therapy Versus Topical Redensyl, Saw Palmetto, and Biotin With Platelet\u2010Rich Plasma Therapy in the Treatment of Androgenetic Alopecia","volume":"15","author":"Tr P.","year":"2023","journal-title":"Cureus"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000462981"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2003.12183.x"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-023-01880-x"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.116730"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2007.03119.x"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-2494.2006.00346.x"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/16546628.2017.1339555"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/cosmetics9060118"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/hr\/uhac011"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2010.534998"},{"key":"e_1_2_11_31_1","article-title":"A Comparative Study Between Topical 5% Minoxidil and Topical \u201cRedensyl, Capixyl, and Procapil\u201d Combination in Men With Androgenetic Alopecia","volume":"5","author":"Karaca N.","year":"2019","journal-title":"Journal of Cosmetology & Trichology"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-7753.188040"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02505040"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.15406\/jdc.2023.07.00247"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/841570"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.16084"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1981.tb135742.x"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70247","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.70247","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70247","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T03:29:46Z","timestamp":1773718186000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.70247"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":36,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1111\/jocd.70247"],"URL":"https:\/\/doi.org\/10.1111\/jocd.70247","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"2025-03-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70247"}}