{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:12:38Z","timestamp":1787015558868,"version":"build-2736575974"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T00:00:00Z","timestamp":1748390400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Demodex<\/jats:italic>\n                      spp. are ectoparasites that reside in pilosebaceous units, particularly on the face where sebum secretion is prominent. The sebum\u2010reducing effects of isotretinoin play a crucial role in the management of acne vulgaris and rosacea. This study aims to assess the effect of isotretinoin on\n                      <jats:italic>Demodex<\/jats:italic>\n                      density in patients with acne vulgaris and rosacea accompanied by demodicosis. The evaluation includes\n                      <jats:italic>Demodex<\/jats:italic>\n                      mite density, before, during, and after 6\u2009months of isotretinoin treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials Methods<\/jats:title>\n                    <jats:p>\n                      The study included patients diagnosed with acne vulgaris and rosacea accompanied by demodicosis who were prescribed isotretinoin treatment. Demographic data were collected, and\n                      <jats:italic>Demodex<\/jats:italic>\n                      spp. mites were detected using superficial skin biopsy before treatment initiation. Follow\u2010up samples were obtained at 2 and 6\u2009months. Statistical analysis was performed using SPSS version 23, with a significance level set at\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 36 patients, 25 with acne and 11 with rosacea, were included in our study.\n                      <jats:italic>Demodex<\/jats:italic>\n                      density was assessed before treatment, at 2\u2009months, and at 6\u2009months. Our findings showed a significant decrease in\n                      <jats:italic>Demodex<\/jats:italic>\n                      density with isotretinoin treatment, especially in relation to the decrease in sebum secretion (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      This study makes a notable contribution to the existing literature by being the first to assess the impact of isotretinoin treatment on\n                      <jats:italic>Demodex<\/jats:italic>\n                      density. Our results indicate that isotretinoin effectively reduces\n                      <jats:italic>Demodex<\/jats:italic>\n                      density, likely due to a reduction in sebum production. To further explore isotretinoin's effects, future research should involve larger sample sizes and extended follow\u2010up periods. These findings enhance our understanding of isotretinoin's role in managing\n                      <jats:italic>Demodex<\/jats:italic>\n                      \u2010related dermatological conditions.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70249","type":"journal-article","created":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T05:03:31Z","timestamp":1748408611000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Therapeutic Modulation of\n                    <i>Demodex<\/i>\n                    Density via Isotretinoin: Insights From a Prospective Dermatological Investigation"],"prefix":"10.1111","volume":"24","author":[{"given":"Ahmed Muayad Jirjees","family":"Chakmakchi","sequence":"first","affiliation":[{"name":"Department of Dermatology Mugla Sitki Kocman University Faculty of Medicine  Mugla 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