{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:52:33Z","timestamp":1790959953398,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,25]],"date-time":"2025-05-25T00:00:00Z","timestamp":1748131200000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Following Nonablative fractional Fraxel laser (NAFL), a well\u2010established treatment for skin rejuvenation, immediate post\u2010procedural care is essential to address any potential complications and accelerate the healing process.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To evaluate the efficacy and patient satisfaction of a topical skincare regimen containing vitamin C, vitamin E, and ferulic acid\u2014CE Ferulic serum (CEF) following NAFL treatment in the Chinese population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this randomized, investigator\u2010blinded, split\u2010face, controlled trial, patients with mild\u2010to\u2010moderate facial photodamage were randomized to receive CEF treatment on one side of the face and normal saline (NS) on the other side immediately after the NAFL procedure and daily during the 7\u2010day follow\u2010up. The primary endpoint was the change from baseline in erythema score on Day 7, with key secondary endpoints including changes from baseline in erythema index (EI), melanin index (MI), transepidermal water loss, skin hydration, skin sebum content, scabbing, edema, overall patient satisfaction, and post\u2010procedure pain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 50 patients (female 45\/50) were enrolled in this study, with a mean age of 31.6\u2009years. The mean change from baseline in erythema score was significantly lower on the CEF side than on the NS side on Day 7 post\u2010NAFL treatment (0.04\u2009\u00b1\u20090.40 vs. 0.18\u2009\u00b1\u20090.48,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.011). The CEF side also exhibited improved changes in EI, MI, and skin hydration, as well as higher overall satisfaction and less pain compared with the NS side.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Applying CEF after NAFL treatment reduced erythema progression, maintained skin hydration, and promoted the healing process compared with NS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>Chinese Clinical Trial Registry: ChiCTR2300069246<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70251","type":"journal-article","created":{"date-parts":[[2025,5,25]],"date-time":"2025-05-25T22:14:42Z","timestamp":1748211282000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A Randomized, Investigator\u2010Blinded, Split\u2010Face, Controlled Trial Assessing Efficacy and Satisfaction of\n                    <scp>CE<\/scp>\n                    Ferulic Serum Following Nonablative Fractional Fraxel Laser Treatment for Photoaging Skin in Chinese Population"],"prefix":"10.1111","volume":"24","author":[{"given":"Xiaolei","family":"Qin","sequence":"first","affiliation":[{"name":"Deyue Clinic  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinlong","family":"Zhai","sequence":"additional","affiliation":[{"name":"Deyue Clinic  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenxi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Dexi Cosmetic Clinic Deyi Skin Institution  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanmei","family":"Wang","sequence":"additional","affiliation":[{"name":"Deyue Clinic  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengjiao","family":"Chen","sequence":"additional","affiliation":[{"name":"Deyue Clinic  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Zhu","sequence":"additional","affiliation":[{"name":"Deyue Clinic  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Shi","sequence":"additional","affiliation":[{"name":"Deyue Clinic  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiliang","family":"Chen","sequence":"additional","affiliation":[{"name":"Dexi Cosmetic Clinic Deyi Skin Institution  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Dexi Cosmetic Clinic Deyi Skin Institution  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Luo","sequence":"additional","affiliation":[{"name":"Dexi Cosmetic Clinic Deyi Skin Institution  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Li","sequence":"additional","affiliation":[{"name":"Dexi Cosmetic Clinic Deyi Skin Institution  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,25]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e13580"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2009.01258.x"},{"issue":"3","key":"e_1_2_12_4_1","first-page":"295","article-title":"The Use of Fractional Laser Photothermolysis for the Treatment of Atrophic Scars","volume":"33","author":"Alster T. S.","year":"2007","journal-title":"Dermatologic Surgery"},{"issue":"1","key":"e_1_2_12_5_1","first-page":"42","article-title":"Update on Fractional Laser Technology","volume":"3","author":"Gold M. H.","year":"2010","journal-title":"Journal of Clinical and Aesthetic Dermatology"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-016-0767-x"},{"issue":"9","key":"e_1_2_12_7_1","first-page":"7","article-title":"Fractional Laser Treatment for Pigmentation and Texture Improvement","volume":"11","author":"Rahman Z.","year":"2006","journal-title":"Skin Therapy Letter"},{"issue":"6","key":"e_1_2_12_8_1","first-page":"51","article-title":"Nonablative Fractional Laser Resurfacing in Skin of Color: Evidence\u2010Based Review","volume":"10","author":"Kaushik S. 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L.Elford C.Oresajo V. P.Bedi andR. G.Geronemus \u201cEnhanced Skin Permeability of C E Ferulic After CLEAR + BRILLIANT Perm\u00e9a Laser Treatment \u201d (2013) https:\/\/www.semanticscholar.org\/paper\/Enhanced\u2010Skin\u2010Permeability\u2010of\u2010C\u2010E\u2010Ferulic\u2010after\u2010%2B\u2010Elford\u2010Oresajo\/247fbb28a4f7e99d0629dd8d08076a9b1b212f83."},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.14153"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70251","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.70251","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70251","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T03:29:18Z","timestamp":1773718158000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.70251"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1111\/jocd.70251"],"URL":"https:\/\/doi.org\/10.1111\/jocd.70251","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"2024-10-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70251"}}