{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T02:03:33Z","timestamp":1793325813530,"version":"4.5.0"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T00:00:00Z","timestamp":1748995200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the safety and efficacy of Botulinum Toxin Type A (BTX\u2010A) injection for the treatment of tear troughs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>This study included patients with tear troughs rated as Grade 1\u20132 on the Barton Aesthetic Scale, who were treated between September 2023 and September 2024. These patients underwent intradermal injections of Botulinum Toxin Type A (BTX\u2010A). Doctors conducted pre\u2010 and post\u2010procedure assessments of the severity of tear troughs using the Barton Scale and TTRS (The Tear Trough Rating Scale). VISIA skin image analyzer (Canfield, USA) was utilized to compare the number of wrinkles, and facial scores and percentiles were calculated for objective evaluations before and after treatment. Additionally, doctors employed the Fitzpatrick Scale to assess periorbital wrinkles. This investigation was conducted as a prospective single\u2010center study (PSS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All 42 patients completed the study. After treatment, there was a significant improvement in VISIA\u2010measured wrinkle count, facial scores, and percentiles. Additionally, there were significant reductions in Barton, TTRS, and Fitzpatrick scores. One case of pseudo\u2010eyelid bags was observed post\u2010treatment, while no other complications such as diplopia, lower eyelid skin laxity, or other adverse effects were reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>BTX\u2010A is effective in improving mild tear troughs while simultaneously reducing fine lines in the lower eyelid. Patients were highly satisfied with the improved appearance.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.70253","type":"journal-article","created":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T15:49:29Z","timestamp":1749052169000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Observation of Safety and Efficacy of Botulinum Toxin Type A in the Treatment of Tear Troughs and Mild Yelid Bags"],"prefix":"10.1111","volume":"24","author":[{"given":"Siyuan","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Medical Cosmetology Second Affiliated Hospital of Guangxi Medical University  Nanning City Guangxi Province China"},{"name":"Guangxi Medical University  Nanning City Guangxi Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5532-5599","authenticated-orcid":false,"given":"Homgtao","family":"Liu","sequence":"additional","affiliation":[{"name":"Guangxi Health Science College  Nanning City Guangxi Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongjie","family":"Pan","sequence":"additional","affiliation":[{"name":"Guangxi Medical University  Nanning City Guangxi Province China"},{"name":"The Second Affiliated Hospital of Guangxi Medical University  Nanning City Guangxi Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuqiang","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Medical Cosmetology Second Affiliated Hospital of Guangxi Medical University  Nanning City Guangxi Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Medical Cosmetology Second Affiliated Hospital of Guangxi Medical University  Nanning City Guangxi Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houhuang","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Medical Cosmetology Second Affiliated Hospital of Guangxi Medical University  Nanning City Guangxi Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingliang","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Medical Cosmetology Second Affiliated Hospital of Guangxi Medical University  Nanning City Guangxi Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liming","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Medical Cosmetology Second Affiliated Hospital of Guangxi Medical University  Nanning City Guangxi Province China"},{"name":"Guangxi Medical University  Nanning City Guangxi Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Medical Cosmetology Second Affiliated Hospital of Guangxi Medical University  Nanning City Guangxi Province China"},{"name":"Guangxi Medical University  Nanning City Guangxi Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,4]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13097"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/prs.0b013e31824ecd77"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.PRS.0000157016.49072.61"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0041-1741498"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjad245"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsc.2021.02.001"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/14764172.2012.738912"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103\u2010022\u201003571\u20107"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.13944"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14768"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266\u2010021\u201002743\u20100"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/14764172.2021.1918341"},{"issue":"12","key":"e_1_2_11_14_1","first-page":"22","article-title":"Evaluation of Intradermal Injection of Botulinum Toxin A for Facial Lifting","volume":"13","author":"Atwa E. M.","year":"2020","journal-title":"Journal of Clinical and Aesthetic Dermatology"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.16142"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.12381"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1996.03890280047007"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1473-2165.2007.00336.x"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.PRS.0000122409.00716.34"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2019.101357"},{"issue":"3","key":"e_1_2_11_21_1","first-page":"168","article-title":"Botulinum Toxin Injection for Facial Wrinkles","volume":"90","author":"Small R.","year":"2014","journal-title":"American Family Physician"},{"issue":"1","key":"e_1_2_11_22_1","first-page":"25","article-title":"Botulinum Toxin\u2014From Poison to Medicine","volume":"158","author":"Davis L. E.","year":"1993","journal-title":"Western Journal of Medicine"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S164848"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000001076"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000001255"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.2003.29257.x"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14279"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266\u2010020\u201001983\u2010w"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjac036"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjprs.2024.07.004"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/IOP.0000000000000282"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70253","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T08:56:43Z","timestamp":1750669003000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.70253"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1111\/jocd.70253"],"URL":"https:\/\/doi.org\/10.1111\/jocd.70253","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"2024-09-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70253"}}