{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T04:01:12Z","timestamp":1769054472236,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T00:00:00Z","timestamp":1749686400000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To study the composition and diversity of microorganisms in skin lesions of patients with facial acne and back acne, analyze the relationship between microorganisms and different parts of acne.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 30 facial acne patients, 30 back acne patients, and 30 healthy controls were included. Comprehensive data on demographics, skin conditions, and state of life were collected. Skin microbiota samples were obtained using standardized protocols, through high\u2010throughput microbial sequencing and bioinformatics analysis, to assess microbiota diversity, composition, and function, as well as their correlations with skin characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The diversity of skin microbiota of back acne patients decreased significantly, and the abundance of <jats:italic>p_actinomycetes<\/jats:italic> and <jats:italic>o_propionate<\/jats:italic> bacteria increased significantly. They are closely related to glucose metabolism, which may lead to increased trans epidermal water loss, decreased skin moisture content, and increased skin oil content.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The skin microbiota diversity of patients with back acne is low, and high\u2010abundance bacteria are closely related to glucose metabolism, which may lead to the breakdown of the skin barrier and increased sebum secretion.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.70259","type":"journal-article","created":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T08:11:32Z","timestamp":1749715892000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Analysis of Skin Microbiome in Facial and Back Acne Patients Based on High\u2010Throughput Sequencing"],"prefix":"10.1111","volume":"24","author":[{"given":"YiJie","family":"Du","sequence":"first","affiliation":[{"name":"School of Light Industry Science and Engineering Beijing Technology &amp; Business University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BenYue","family":"Li","sequence":"additional","affiliation":[{"name":"Shandong Huawutang Biotechnology Co., Ltd  Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Yang","sequence":"additional","affiliation":[{"name":"Shandong Huawutang Biotechnology Co., Ltd  Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YeXiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shandong Huawutang Biotechnology Co., Ltd  Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"FengWei","family":"Qi","sequence":"additional","affiliation":[{"name":"Shandong Huawutang Biotechnology Co., Ltd  Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Meng","sequence":"additional","affiliation":[{"name":"International School of Cosmetics, School of Light Industry Science and Engineering Beijing Technology &amp; Business University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.10.033"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.17981"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18659"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1002533"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11234"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.18616"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/12034754211037994"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.14952"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12275-021-0647-1"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-021-00586-6"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD011368.pub2"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abo0693"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms10091874"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep18761"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13296"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph16010087"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-021-09074-y"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15043"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-023-00789-1"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms9030628"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13397"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2015.12.024"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01286-14"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2022.154101"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.16092"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70259","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T08:56:29Z","timestamp":1750668989000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.70259"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1111\/jocd.70259"],"URL":"https:\/\/doi.org\/10.1111\/jocd.70259","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"2024-11-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70259"}}