{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:48:04Z","timestamp":1781484484572,"version":"3.54.1"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T00:00:00Z","timestamp":1749686400000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Postinjection alopecia is a rare but significant complication of facial fillers, likely caused by compromised microcirculation and follicular damage. Effective treatments are needed, but regenerative therapies specifically for this etiology lack systematic investigation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study evaluated the efficacy and safety of combined autologous chylated fat (ACF) and concentrated growth factors (CGF) for treating acute alopecia following facial filler injection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this single\u2010center, retrospective case series, nine female patients with acute alopecia (2\u20134\u2009weeks post\u2010HA filler) were treated between June 2021 and June 2024. Treatment involved three monthly subcutaneous injections of a 1:1 ACF and liquid CGF mixture (0.1\u2009mL\/cm<jats:sup>2<\/jats:sup>). Outcomes were assessed at 6\u2009months posttreatment initiation, including hair density, diameter, terminal\/vellus ratio, anagen\/telogen ratio, Global Aesthetic Improvement Scale (GAIS), and adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All nine patients completed the 6\u2010month follow\u2010up. Significant improvements (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) were observed at 6\u2009months compared to baseline: hair density increased from 32.7\u2009\u00b1\u200913.4 to 92.4\u2009\u00b1\u200923.4 hairs\/cm<jats:sup>2<\/jats:sup>, hair diameter from 52.3\u2009\u00b1\u200915.2 to 75.8\u2009\u00b1\u200921.7\u2009\u03bcm, terminal\/vellus ratio from 0.31\u2009\u00b1\u20090.11 to 1.27\u2009\u00b1\u20090.35, and anagen proportion from 18.4%\u2009\u00b1\u20096.5% to 63.7%\u2009\u00b1\u200914.9%. GAIS scores indicated high satisfaction. Treatment was well\u2010tolerated, with only one patient reporting transient erythema.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Combined ACF and CGF represent a promising and effective treatment for post\u2010filler alopecia, offering a novel therapeutic option for early intervention and improved esthetic outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.70269","type":"journal-article","created":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T08:05:26Z","timestamp":1749715526000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Clinical Efficacy of Composite Autologous Chylated Fat and Concentrated Growth Factors for Treating Postinjection Alopecia After Facial Fillers: A Single\u2010Center Retrospective Study"],"prefix":"10.1111","volume":"24","author":[{"given":"Shuo","family":"Tang","sequence":"first","affiliation":[{"name":"Senior Department of Burns and Plastic Surgery 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