{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T14:55:04Z","timestamp":1788274504160,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T00:00:00Z","timestamp":1749168000000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The treatment of acne scars has always been challenging. In the past, its gold standard treatment was carbon dioxide (CO<jats:sub>2<\/jats:sub>) fractional laser, but its efficacy rate was only 51%\u201370%. The use of poly\u2010L\u2010lactic acid (PLLA) has provided a new treatment strategy. In this study, a novel PLLA material was used in combination with a CO<jats:sub>2<\/jats:sub> fractional laser to treat acne scars, and its safety and effectiveness were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To determine the safety and effectiveness of PLLA (Loviselle) combined with a CO<jats:sub>2<\/jats:sub> fractional laser in the treatment of acne scars.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this study, 60 patients were randomly divided into two groups, with 30 patients in each group. Group A received only CO<jats:sub>2<\/jats:sub> fractional laser treatment, whereas Group B received injections of PLLA 1, 3, and 5\u2009months after CO<jats:sub>2<\/jats:sub> fractional laser treatment. Both groups were followed up for 6\u2009months after the CO<jats:sub>2<\/jats:sub> fractional laser treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were statistically significant differences in the Quantitative Global Scarring Grading System (GSS) scores between the two groups before and after treatment. Group B had lower GSS scores than Group A. In the treatment of different types of acne scars using the Acne Scar Rating Scale, the improvement in rolling scars was greater than that in boxcar scars, and both were greater than those in ice\u2010pick scars. Whether evaluated by independent physicians' assessment of treatment improvement or patients' satisfaction questionnaire, the combined treatment group showed better results than the single treatment group, and there were statistically significant differences between the two groups. Adverse reactions included transient redness, bruising, and pigmentation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The combination of CO<jats:sub>2<\/jats:sub> fractional laser and PLLA can safely and effectively treat acne scars, especially rolling and boxcar depressed scars.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.70271","type":"journal-article","created":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T12:10:17Z","timestamp":1749211817000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Poly\u2010L\u2010Lactic Acid Combined With <scp>CO<sub>2<\/sub><\/scp> Fractional Laser for the Treatment of Acne Scars"],"prefix":"10.1111","volume":"24","author":[{"given":"Chenxi","family":"Zhou","sequence":"first","affiliation":[{"name":"DEXI Clinc, DE YI Skin  Xi'an Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiliang","family":"Chen","sequence":"additional","affiliation":[{"name":"DEXI Clinc, DE YI Skin  Xi'an Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"DEXI Clinc, DE YI Skin  Xi'an Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Luo","sequence":"additional","affiliation":[{"name":"DEXI Clinc, DE YI Skin  Xi'an Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Zhu","sequence":"additional","affiliation":[{"name":"DEYUE Clinc, DE YI Skin  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erting","family":"Zhang","sequence":"additional","affiliation":[{"name":"DEYUE Clinc, DE YI Skin  Shenzhen 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