{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T22:07:18Z","timestamp":1782338838782,"version":"3.54.5"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T00:00:00Z","timestamp":1748995200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Androgenetic alopecia (AGA) is the most prevalent form of hair loss, often leading to treatment discontinuation due to the adverse effects and perceived ineffectiveness of conventional treatments. Botanical extracts are gaining attention for their potential benefits in managing AGA with minimal side effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To evaluate the efficacy and safety of a shampoo and hair tonic containing Asacurin100, a botanical extract blend, in improving hair loss conditions in patients with AGA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective single\u2010group, pretest\u2013posttest study was conducted with 35 male participants diagnosed with AGA at a Korean medicine clinic. Participants applied the shampoo once daily and the hair tonic two to three times daily for 6\u2009months. Data were collected via standardized global scalp photographs and a custom\u2010designed questionnaire assessing scalp symptoms. Statistical analyses were performed to evaluate changes in hair loss area and subjective symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study observed reductions in hair loss area, with a mean decrease of \u221227.35\u2009\u00b1\u200926.31 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001), and improvement in all scalp symptom scores. The Patient Global Impression of Change (PGIC) revealed that 80% of participants reported \u201cmuch\u201d or \u201cvery much\u201d improvement in hair condition. No serious adverse events were reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The findings suggest that botanical extract\u2013infused shampoo and hair tonic are effective and well\u2010tolerated treatments for AGA, reducing hair loss and enhancing scalp health. The results warrant further investigation through larger randomized controlled trials to validate the efficacy of plant\u2010derived compounds for AGA.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.70273","type":"journal-article","created":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T03:28:32Z","timestamp":1749094112000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Botanical Extract\u2013Infused Shampoo and Hair Tonic for Hair Loss in Androgenetic Alopecia: A <scp>TREND<\/scp>\u2010Compliant, Prospective Single\u2010Arm Preexperimental Study"],"prefix":"10.1111","volume":"24","author":[{"given":"Dong\u2010Gi","family":"Choi","sequence":"first","affiliation":[{"name":"Cheonho Kyunghee Korean Medicine Clinic  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8082-7558","authenticated-orcid":false,"given":"Woo\u2010Chul","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Korean Rehabilitation Medicine Kyung Hee University, College of Korean Medicine, Kyung Hee University Korean Medicine Hospital  Seoul Republic of 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