{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:57:03Z","timestamp":1790812623396,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T00:00:00Z","timestamp":1750291200000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The 1927\u2010nm nonablative fractional laser is widely used for skin rejuvenation and hyperpigmentation. However, its efficacy and safety for periorbital rejuvenation remain uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To assess the effects of the 1927\u2010nm nonablative fractional diode laser on periorbital rejuvenation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients\/Methods<\/jats:title>\n                    <jats:p>Twenty participants were randomized into two groups and received three treatments at 2\u2010week (Group A) or 4\u2010week (Group B) intervals. Clinical efficacy was assessed using ANTERA 3D, blinded investigator\u2010rated scores, and subject self\u2010assessments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Both group A and group B exhibited statistically significant improvements in L* (color measurement which indicates lightness) and pigmentation score at the end\u2010of\u2010study visit compared to baseline, with group B also achieving statistically significant enhancement in the pores' index and wrinkles' score. Group B showed greater improvement in wrinkles' score compared to group A at the end\u2010of\u2010study visit. The median of Global Aesthetic Improvement Scale assessed by both the physicians and subjects showed improvement, ranging from \u201cimproved\u201d to \u201cmuch improved\u201d at the end\u2010of\u2010study visit. Transient side effects including tenderness, erythema, swelling, and scaling were observed, with the majority resolving within 7\u2009days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The 1927\u2010nm diode laser is an effective and safe option for periorbital rejuvenation. The 4\u2010week interval treatment appears to be the preferable option due to its superior improvement in the wrinkles' score at the end of the study. The positive changes in skin brightness and the reduction of brown spots represented additional benefits, setting it apart as a notable alternative to other ablative and nonablative fractional lasers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70274","type":"journal-article","created":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T07:21:09Z","timestamp":1750317669000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Nonablative Fractional 1927\u2010nm Laser for Periorbital Rejuvenation: A Prospective, Double\u2010Arm, Open\u2010Label Trial"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5432-0163","authenticated-orcid":false,"given":"Chang\u2010Ming","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Dermatology National Taiwan University Hospital  Taipei Taiwan"},{"name":"Department of Dermatology National Taiwan University Hospital Hsin\u2010Chu Branch  Hsinchu Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8743-7496","authenticated-orcid":false,"given":"Yi\u2010Shuan","family":"Sheen","sequence":"additional","affiliation":[{"name":"Department of Dermatology National Taiwan University Hospital  Taipei Taiwan"},{"name":"Department of Dermatology, College of Medicine National Taiwan University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Hua","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Dermatology National Taiwan University Hospital  Taipei Taiwan"},{"name":"Department of Dermatology, College of Medicine National Taiwan University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,19]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joco.2017.04.001"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjv079"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2018.3320"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.14031"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.15171\/jlms.2019.S12"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.11.044"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/cxo.13117"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-020-02173-z"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/14764172.2016.1157370"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2004.30160.x"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-967752"},{"issue":"8","key":"e_1_2_11_13_1","first-page":"3","article-title":"The 1440 nm and 1927 nm Nonablative Fractional Diode Laser: Current Trends and Future Directions","volume":"19","author":"Friedman P. 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