{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T01:56:53Z","timestamp":1755223013064,"version":"3.43.0"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T00:00:00Z","timestamp":1748995200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100020638","name":"Allergan Aesthetics","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020638","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Many skin disorders of the face have an inflammatory element, including atopic dermatitis, acne vulgaris, and rosacea. VYC\u201012 is an injectable hyaluronic acid product with well\u2010established hydrating effects and potential anti\u2010inflammatory benefits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To assess the utility of VYC\u201012 for improving inflammatory skin conditions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a single\u2010center, retrospective analysis of adults with a facial inflammatory skin condition that was resistant to standard treatments. A small group was also included who only required treatment for aging\u2010related concerns. VYC\u201012 was injected into the deep dermis based on the standard technique. Imaging was used to assess skin redness and stratum corneum moisture levels. Patient satisfaction was evaluated on a five\u2010point Likert scale, and adverse events were recorded throughout a mean follow\u2010up of 4\u2009months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifteen patients were included (86.7% female; mean age: 40.5\u2009\u00b1\u20099.7\u2009years). Four had atopic dermatitis, 4 had acne vulgaris, and 2 had rosacea; the other 5 had aging\u2010related dryness and fine lines. Patients received a mean of 3.4\u2009\u00b1\u20091.2\u2009mL of VYC\u201012. Among 10 individuals with an inflammatory skin condition, mean skin redness decreased from 57.7 (arbitrary units) at baseline to 47.9 at 4\u2009months post\u2010treatment (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0005); mean stratum corneum moisture levels increased from 45.1 (arbitrary units) to 75.3 over this period (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0005). All 15 subjects were satisfied with the results. There were no adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>VYC\u201012 significantly improved skin redness and hydration in patients with inflammatory skin disorders. Further studies are warranted to assess the benefits of combining VYC\u201012 with standard treatments.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.70275","type":"journal-article","created":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T11:21:40Z","timestamp":1749727300000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Skin Improvement in Japanese Patients With Inflammatory Dermatologic Conditions Using the Injectable Hyaluronic Acid <scp>VYC<\/scp>\u201012"],"prefix":"10.1111","volume":"24","author":[{"given":"Chiharu","family":"Watanabe","sequence":"first","affiliation":[{"name":"Chiharu Dermatology Clinic  Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,4]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S262691"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S467934"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.17040"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S216222"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000003802"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.5b00181"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.36849\/JDD.2020.10.36849\/JDD.2020.4856"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103\u2010020\u201003145\u20105"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.15027"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000002723"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S352007"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13129"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjad111"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000001932"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/hsr2.399"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.23736\/S2784\u20108671.19.06453\u20108"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000003359"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000003613"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000534136"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266\u2010024\u201004046\u20106"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdin.2020.10.006"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S239667"},{"issue":"1","key":"e_1_2_12_24_1","first-page":"31","article-title":"Aging Differences in Ethnic Skin","volume":"9","author":"Vashi N. 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