{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T11:35:34Z","timestamp":1789731334022,"version":"4.0.1"},"reference-count":97,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T00:00:00Z","timestamp":1749772800000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073453"],"award-info":[{"award-number":["82073453"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Photoaging, caused by long\u2010term ultraviolet (UV) exposure, leads to wrinkles, loss of skin elasticity, pigmentation disorders, and impaired barrier function due to oxidative stress, DNA damage, and collagen breakdown. Hydrogels, with their high water content (&gt;\u200990%), biocompatibility, and controlled drug release capabilities, have emerged as a powerful tool for preventing and treating skin photoaging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To review current treatment strategies and provide an updated perspective on the treatment of photoaging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched the PubMed and Web of Science library databases for eligible studies published within the past 5\u2009years, categorizing and evaluating the effects of hydrogels with different carriers and active ingredients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 21 relevant studies were included, involving Lipid\u2010based Hydrogels, Hyaluronic Acid\u2010based Hydrogels, Chitosan\u2010based Hydrogels, Polyacrylonitrile\u2010modified <jats:italic>\u03ba<\/jats:italic>\u2010Carrageenan\u2010based Hydrogels, Gellan Gum\/Sodium Alginate\u2010based Hydrogels, Recombinant Collagen\u2010based Hydrogels, and Other Polymer\u2010based Hydrogels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The collected studies consistently demonstrate that hydrogel therapy is more effective than traditional treatments in reducing UV\u2010induced skin damage and promoting skin repair and regeneration. In addition to improving drug utilization efficiency, hydrogel carriers\u2014particularly those incorporating hyaluronic acid\u2014enhance skin hydration, slow aging, and accelerate wound healing, indicating promising therapeutic potential.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.70295","type":"journal-article","created":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T01:08:36Z","timestamp":1750381716000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Hydrogel\u2010Based Therapies for Photoaging: Current Advances and Future Perspectives"],"prefix":"10.1111","volume":"24","author":[{"given":"Qiong","family":"Gao","sequence":"first","affiliation":[{"name":"Center for Plastic and Reconstructive Surgery, Department of Dermatology, Zhejiang Provincial People's Hospital Affiliated People's Hospital of Hangzhou Medical College  Hangzhou People's Republic of China"},{"name":"Zhejiang Chinese Medical University  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