{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:03:16Z","timestamp":1791406996060,"version":"4.3.3"},"reference-count":12,"publisher":"Wiley","issue":"S3","license":[{"start":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T00:00:00Z","timestamp":1753401600000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      The A.G.E. Interrupter serum has been developed in an oil\u2010in\u2010water emulsion to contain 30% proxylane,\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Cassia alata<\/jats:italic>\n                      <\/jats:styled-content>\n                      extract, blueberry and pomegranate extract, rhamnose, and gentiana lutea root extract. The technology has several patent ingredients as well as synergistic patents with proxylane, rhamnose, and new ones submitted for the new ingredients. An ex\u00a0vivo model using this final formulation has shown upregulation of laminin\u20105, collagen IV, tropoelastin, and collagen III. Collagen IV and laminin are present in the dermal\u2010epidermal junction (DEJ) and are factors in the basement membrane function. Over time, the DEJ decreases in height and in surface area, leading to weakened skin integrity and structure. The serum was tested to illustrate visible life in the jawline, forehead, cheek, and neck as well as instrumental testing showing visible improvement in the nasolabial fold and forehead wrinkle.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To present a real\u2010world case series that demonstrates the use of the A.G.E. Interrupter serum as an adjunctive therapy to collagen\u2010stimulating procedures in a wide variety of patient ages and skin types.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Eight internationally recognized, licensed dermatologists with extensive experience in cosmetic and facial rejuvenation procedures were selected to participate in an expert panel. During the expert panel, dermatologists were asked to share 2 cases using the A.G.E. Interrupter serum in patients undergoing collagen\u2010stimulating procedures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Following the panel discussion, seven patient cases were selected to illustrate the use of the A.G.E. Interrupter serum in conjunction with collagen\u2010stimulating procedures to optimize patient outcomes and satisfaction. Experts found that daily A.G.E. Interrupter serum application post\u2010procedure led to improved overall results and high patient satisfaction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case series provides evidence for different integrated skincare regimens using the A.G.E. Interrupter serum in a variety of patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70302","type":"journal-article","created":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T11:43:53Z","timestamp":1753443833000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Real World Case Series: A.G.E. Interrupter Ultra Serum"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7643-6404","authenticated-orcid":false,"given":"Sonya","family":"Abdulla","sequence":"first","affiliation":[{"name":"Dermatology on Bloor  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5449-7104","authenticated-orcid":false,"given":"Patricia","family":"Brieva","sequence":"additional","affiliation":[{"name":"SkinCeuticals  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugues","family":"Cartier","sequence":"additional","affiliation":[{"name":"Clinic Saint\u2010Jean  Arras France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Dierickx","sequence":"additional","affiliation":[{"name":"SkinPeriu III  Bertrange Luxembourg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0161-5723","authenticated-orcid":false,"given":"Sophie","family":"Gu\u00e9nin","sequence":"additional","affiliation":[{"name":"Mount Sinai Dermatology  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7313-4815","authenticated-orcid":false,"given":"Ariel","family":"Haus","sequence":"additional","affiliation":[{"name":"Dr Haus Dermatology  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jani","family":"van Loghem","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Amsterdam  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Shahbaz","sequence":"additional","affiliation":[{"name":"Westlake Dermatology and Cosmetic Surgery  Austin Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaus","family":"Schicher","sequence":"additional","affiliation":[{"name":"Dr. Nikolaus Schicher Dermatology  Klagenfurt Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3031-1390","authenticated-orcid":false,"given":"Peter","family":"Bjerring","sequence":"additional","affiliation":[{"name":"Department of Dermatology Aalborg University Hospital  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,25]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.77.032207.120833"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.20517\/2347\u20109264.2020.153"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-04856-1"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.837222"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12079-021-00654-y"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/bioengineering8110148"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21010073"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/ics.12523"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.15904"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.19606"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13596-020-00447-5"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2016.03.006"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70302","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.70302","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70302","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T09:49:24Z","timestamp":1774345764000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.70302"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":12,"journal-issue":{"issue":"S3","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1111\/jocd.70302"],"URL":"https:\/\/doi.org\/10.1111\/jocd.70302","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"2025-04-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70302"}}