{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T00:16:45Z","timestamp":1781914605477,"version":"3.54.5"},"reference-count":12,"publisher":"Wiley","issue":"S2","license":[{"start":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T00:00:00Z","timestamp":1753401600000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Skin aging is a multifactorial process with intrinsic and extrinsic factors that lead to visible signs of aging, including loss of skin elasticity, volume, dyspigmentation, wrinkles, fine lines, and dry and uneven skin. The advanced RGN\u20106 serum is a patent\u2010pending, multi\u2010ingredient serum that has been developed to address 6 dimensions of skin regeneration and combat visible signs of aging. The six dimensions of skin regeneration include: (1) barrier re\u2010epithelialization, (2) redness and inflammation, (3) cellular energy stimulation, (4) elastin and collagen stimulation, (5) antioxidants, and (6) postinflammatory hyperpigmentation (PIH). To address these factors, the RGN\u20106 serum contains six active ingredients: 1% eperuline, 0.2% ectoin, 10% glycorepair, 0.2% bioceramide 603, 3% acetyl tetrapeptide\u20109, and 2% niacinamide. This multi\u2010ingredient serum works to simultaneously target the most common signs of aging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To provide detailed evidence for multiple integrated skincare regimens using the advanced RGN\u20106 serum in facial rejuvenation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this real\u2010world case series, 6 expert dermatologists with extensive experience in cosmetic and anti\u2010aging medicine shared and discussed patient cases of advanced RGN\u20106 serum used in combination with energy\u2010based facial rejuvenation procedures in a subset of women with skin of color with Fitzpatrick skin types ranging from type 3 to type 6.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>After the panel discussion, six patient cases were selected to best demonstrate the use of RGN\u20106 serum postprocedure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The panel experts agreed that twice daily application of the RGN\u20106 serum led to improved signs of redness, fine lines, and skin tone and evenness in all postprocedure patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70303","type":"journal-article","created":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T11:49:31Z","timestamp":1753444171000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Real World Case Series: Integrated Skincare With Advanced\n                    <scp>RGN<\/scp>\n                    \u20106 Serum"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1351-9165","authenticated-orcid":false,"given":"Andrew","family":"Alexis","sequence":"first","affiliation":[{"name":"Weill Cornell Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4441-2387","authenticated-orcid":false,"given":"Ren\u00e9e A.","family":"Beach","sequence":"additional","affiliation":[{"name":"DermAtelier on Avenue Faculty of Medicine University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5449-7104","authenticated-orcid":false,"given":"Patricia","family":"Brieva","sequence":"additional","affiliation":[{"name":"SkinCeuticals  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0161-5723","authenticated-orcid":false,"given":"Sophie","family":"Gu\u00e9nin","sequence":"additional","affiliation":[{"name":"Mount Sinai Dermatology  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4787-3460","authenticated-orcid":false,"given":"Omar A.","family":"Ibrahimi","sequence":"additional","affiliation":[{"name":"Connecticut Skin Institute  Milford Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9747-1882","authenticated-orcid":false,"given":"Michelle","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Chroma Dermatology, Clinical Department of Dermatology Royal Children's Hospital  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5528-8791","authenticated-orcid":false,"given":"Heather","family":"Woolery\u2010Lloyd","sequence":"additional","affiliation":[{"name":"Skin of Color Division Dr Phillip Frost Department of Dermatology and Cutaneous Surgery University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1297-5270","authenticated-orcid":false,"given":"Valerie","family":"Callender","sequence":"additional","affiliation":[{"name":"Howard University College of Medicine, Callender Dermatology &amp; Cosmetic Center  Glenn Dale Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,25]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1354.044"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-021-00080-0"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2016.09.015"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-2494.2004.00241.x"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.16688"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000080216"},{"key":"e_1_2_12_8_1","first-page":"200","article-title":"Efficacy Evaluation and Stability Study of a Multifunctional Cosmetic Cream Containing Antioxidants, Phyto\u2010Steroids and Acetyl Tetrapeptide\u20109","author":"Papageorgiou S.","year":"2015","journal-title":"SCinTE"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09477.x"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.15904"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-021-00676-9"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241512104"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-2494.2004.00228.x"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70303","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.70303","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70303","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T09:49:25Z","timestamp":1774345765000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.70303"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":12,"journal-issue":{"issue":"S2","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1111\/jocd.70303"],"URL":"https:\/\/doi.org\/10.1111\/jocd.70303","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"2025-04-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70303"}}