{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:11:46Z","timestamp":1787015506839,"version":"build-2736575974"},"reference-count":59,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T00:00:00Z","timestamp":1752192000000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005137","name":"L'Oreal USA","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005137","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005825","name":"National Institute of Food and Agriculture","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005825","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Premature skin aging and the growing incidence of skin conditions are closely linked to daily exposure to environmental agents. Among all air pollutants, particulate matter (PM) is regarded as one of the most aggressive in terms of skin damage, promoting degradation of extracellular matrix (ECM) components and depletion of the cutaneous antioxidant defense via initiation of oxinflammatory reactions. Moreover, PM can penetrate damaged skin, exacerbating the effect of other pollutants and worsening the symptoms of existing skin conditions. Topical application of antioxidant compounds can limit and, in certain cases, even prevent skin damage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>In the present study, a randomized clinical study was conducted to evaluate the protective effects of a topically applied antioxidant serum containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol (AOX Mix) against the PM\u2010induced skin damage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>For this purpose, the back of 15 female volunteers, between 19\u201340\u2009years and with skin phototypes III and IV, was pre\u2010treated with AOX Mix and exposed daily to PM for 4\u2009days. Skin sample biopsies were subsequently collected and subjected to histological analysis to evaluate the key markers related to skin \u201coxinflammaging\u201d.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The AOX Mix demonstrated protective effects against the cutaneous degradation of ECM components, including type I and III collagens, elastin, and tropoelastin. It also mitigated markers of inflammation (COX2), oxidative stress (4\u2010hydroxynonenal), and structural damage (involucrin, filaggrin, claudin\u20101, desmocollin 1).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Regular topical application of an antioxidant cosmeceutical formulation represents an effective strategy to counteract the detrimental effects of environmental insults, particularly with respect to inflammaging.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70306","type":"journal-article","created":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T09:19:52Z","timestamp":1752225592000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Application of Antioxidant Mixture Prevents Cutaneous \u201cOxinflammaging\u201d in Subjects Exposed to Particulate Matter"],"prefix":"10.1111","volume":"24","author":[{"given":"John","family":"Ivarsson","sequence":"first","affiliation":[{"name":"Department of Food, Bioprocessing and Nutrition Sciences Plants for Human Health Institute, NC Research Campus, NC State University  Kannapolis North Carolina USA"},{"name":"Department of Animal Sciences Plants for Human Health Institute, NC Research Campus, NC State University  Kannapolis North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Yan","sequence":"additional","affiliation":[{"name":"L'Or\u00e9al Research and Innovation  Clark New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Guiotto","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences Plants for Human Health Institute, NC Research Campus, NC State University  Kannapolis North Carolina 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