{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T17:01:06Z","timestamp":1774630866097,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T00:00:00Z","timestamp":1750636800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Botulinum toxin A (BoNT\u2010A) is the most used procedure to treat glabellar lines; however, limited data exist about the effectiveness of ready\u2010to\u2010use BoNT\u2010A (RTUaboBoNT\u2010A) for this indication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>This study compared the efficacy, durability, and safety of RTUaboBoNT\u2010A for moderate and severe glabellar wrinkles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This randomized triple\u2010blinded trial included 38 male volunteers aged between 25 and 50\u2009years. Participants were randomly divided into two groups: abobotulinumtoxinA (aboBoNT\u2010A, <jats:italic>n<\/jats:italic>\u2009=\u200918) and RTUaboBoNT\u2010A (<jats:italic>n<\/jats:italic>\u2009=\u200920). Groups received 10\u2009U for procerus muscle and 20\u2009U for the corrugator muscle. Assessed variables included, electromyography activity (EMG), Merz 5\u2010point glabellar lines scale, FACE\u2010Q appraisal for lines between the eyebrows and Visual Analogue Scale for pain intensity. Assessments were performed before and 1, 2, 3, and 4\u2009months after injections. For differences in EMG and satisfaction scores, the two\u2010way repeated\u2010measures ANOVA and Bonferroni's post hoc analyses were conducted. Wrinkle severity scores were analyzed with the chi\u2010squared test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Inter\u2010group comparisons revealed no significant differences in EMG scores in all assessed periods for the corrugator supercili (<jats:italic>p<\/jats:italic>\u2009=\u20090.11) and the procerus muscles (<jats:italic>p<\/jats:italic>\u2009=\u20090.93); for severity of glabellar lines, no significant differences were also found in all follow\u2010ups for rest (<jats:italic>p<\/jats:italic>\u2009=\u20090.737) and contracted position (<jats:italic>p<\/jats:italic>\u2009=\u20090.390), as well as for satisfaction with the treatments. However, the RTUaboBoNT\u2010A group presented higher levels of pain intensity during the injection procedure (<jats:italic>p<\/jats:italic>\u2009=\u20090.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The RTUaboBoNT\u2010A and aboBoNT\u2010A are comparable in efficacy, durability, and safety.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.70308","type":"journal-article","created":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T03:43:27Z","timestamp":1750650207000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Comparing Ready\u2010to\u2010Use and Powder <scp>AbobotulinumtoxinA<\/scp> for Glabellar Lines: A Randomized, Controlled, Triple\u2010Blinded Clinical Trial"],"prefix":"10.1111","volume":"24","author":[{"given":"Silvio Ventura","family":"da Silva Junior","sequence":"first","affiliation":[{"name":"Department of Dentistry Ing\u00e1 University Center, Uning\u00e1  Maring\u00e1 Paran\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Luiza Boechat","family":"Borges Neves","sequence":"additional","affiliation":[{"name":"Department of Dentistry Ing\u00e1 University Center, Uning\u00e1  Maring\u00e1 Paran\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfonso","family":"Sanchez\u2010Ayala","sequence":"additional","affiliation":[{"name":"Department of Dentistry University of Ponta Grossa  Ponta Grossa Paran\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro Miguel Teixeira Carvas","family":"Cebola","sequence":"additional","affiliation":[{"name":"Egas Moniz Center for Interdisciplinary Research (CiiEM), Egas Moniz School of Health &amp; Science  Caparica, Almada Portugal"},{"name":"Orofacial Pain Unit CUF Tejo Hospital  Lisboa Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Claudia","family":"Carbone","sequence":"additional","affiliation":[{"name":"Department of Dentistry Ing\u00e1 University Center, Uning\u00e1  Maring\u00e1 Paran\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana Barbosa","family":"C\u00e2mara\u2010Souza","sequence":"additional","affiliation":[{"name":"Department of Dentistry Ing\u00e1 University Center, Uning\u00e1  Maring\u00e1 Paran\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo Lorenzi","family":"Poluha","sequence":"additional","affiliation":[{"name":"Department of Dentistry State University of Maring\u00e1  Maring\u00e1 Paran\u00e1 Brazil"},{"name":"Orofacial Institute of the Americas \u2013 IOA Maring\u00e1  Maring\u00e1 Paran\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0921-342X","authenticated-orcid":false,"given":"Giancarlo","family":"De la Torre Canales","sequence":"additional","affiliation":[{"name":"Department of Dentistry Ing\u00e1 University Center, Uning\u00e1  Maring\u00e1 Paran\u00e1 Brazil"},{"name":"Egas Moniz Center for Interdisciplinary Research (CiiEM), Egas Moniz School of Health &amp; Science  Caparica, Almada Portugal"},{"name":"Division of Oral Diagnostics and Rehabilitation, Department of Dental Medicine Karolinska Institutet  Huddinge Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,23]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524\u20104725.2006.32339.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2015.07.003"},{"key":"e_1_2_10_4_1","unstructured":"\u201cISAPS International Survey on Esthetic\/Cosmetic Procedures Performed in 2023 \u201d accessed January 17 2025 https:\/\/www.isaps.org\/media\/rxnfqibn\/isaps\u2010global\u2010survey_2023.pdf."},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjac253"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/iop.0000000000002491"},{"issue":"2","key":"e_1_2_10_7_1","first-page":"31","article-title":"Comparison and Overview of Currently Available Neurotoxins","volume":"7","author":"Walker T. J.","year":"2014","journal-title":"Journal of Clinical and Aesthetic Dermatology"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/psn.0000000000000121"},{"key":"e_1_2_10_9_1","unstructured":"Alluzience \u201cAlluzience 200 Speywood Units\/ml Solution for Injection \u2013 ENG SmPC \u201d accessed January 5 2025 https:\/\/www.lakemedelsverket.se\/sv\/sok\u2010lakemedelsfakta\/lakemedel?id=20191122000079."},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjw272"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjz003"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjz248"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.16359"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/14764172.2010.514920"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468\u20103083.2010.03631.x"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjad222"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cps.2012.12.001"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2011.07.005"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100041\u20101725168"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjab329"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555\u20101647"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555\u20102093"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.iio.0000167237.49396.7b"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rehab.2016.07.331"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2015.2232"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.111780"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70308","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T05:31:37Z","timestamp":1755581497000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.70308"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,23]]},"references-count":25,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1111\/jocd.70308"],"URL":"https:\/\/doi.org\/10.1111\/jocd.70308","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,23]]},"assertion":[{"value":"2025-02-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70308"}}