{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T08:30:11Z","timestamp":1776501011343,"version":"3.51.2"},"reference-count":5,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T00:00:00Z","timestamp":1751414400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Mechanical Dermal Micro\u2010Coring Technology (MCT; Ellacor System) achieves skin tightening and wrinkle reduction through direct mechanical excision of skin cores using hollow needles and collagen stimulation via the wound\u2010healing response.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To evaluate histopathology and immunohistochemistry of the skin and subcutaneous tissue after a single and multiple treatments with MCT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients\/Methods<\/jats:title><jats:p>In this single\u2010center pilot study, 6 female patients scheduled to undergo abdominoplasty were divided into 2 cohorts. Subjects in cohort 1 (safety cohort) received 1 MCT treatment at a depth of 4\u2009mm, 5\u2009mm, and 7\u2009mm, each administered at 1 of 3 unique test areas, with tissue sampling\/abdominoplasty 30\u2009days after treatment. Subjects in cohort 2 received 1, 2, or 3 4\u2009mm\u2010depth treatments at 1 of 3 unique test sites, with 30\u2010day intervals for &gt;\u20091 treatment. Tissue sampling\/abdominoplasty occurred 90\u2009days after initial treatment. Histopathology was performed at a central laboratory, and biopsies were evaluated using H&amp;E, Herovici, and Movat stains by blinded evaluators.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A robust increase in new collagen compared to the control tissue was observed for 1 to 3 treatments in all samples. There was no evidence of inflammation or scarring, consistent with earlier preclinical and clinical histology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>MCT\u2010associated histological changes confirm that in addition to skin removal, treatment results in an increase in collagen and homogenization of the dermis in the treated area.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.70323","type":"journal-article","created":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T10:34:10Z","timestamp":1751452450000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Histologic Study of Abdominal Skin Treated With Mechanical Dermal Micro\u2010Coring Technology for Minimally Invasive Skin Removal"],"prefix":"10.1111","volume":"24","author":[{"given":"Ashish C.","family":"Bhatia","sequence":"first","affiliation":[{"name":"Associate Professor of Clinical Dermatology Northwestern University, Feinberg School of Medicine  Chicago Illinois USA"},{"name":"Adjunct Associate Professor of Clinical Dermatology Rush University School of Medicine  Chicago Illinois USA"},{"name":"Co\u2010Director of Dermatologic, Laser &amp; Cosmetic Surgery and Medical Director for Dermatologic Research, Oak Dermatology  Naperville Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl","family":"Napekoski","sequence":"additional","affiliation":[{"name":"Dermatopathologist at Midwest Diagnostic Pathology  Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jill","family":"Edgecombe","sequence":"additional","affiliation":[{"name":"Independent Consultant  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Weir","sequence":"additional","affiliation":[{"name":"Mr. Weir Is a NP in Private Practice at Dallas Plastic Surgery Institute  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachelle","family":"Winkle","sequence":"additional","affiliation":[{"name":"Ms. Winkle Is an RN in Private Practice at Dallas Plastic Surgery Institute in Dallas  Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rod","family":"Rohrich","sequence":"additional","affiliation":[{"name":"Dr. Rohrich Is a Plastic Surgeon in Private Practice at Dallas Plastic Surgery Institute  Dallas Texas USA"},{"name":"A Clinical Professor of Plastic Surgery\u2010Baylor College of Medicine  Houston Texas USA"},{"name":"A Professor of Plastic Surgery University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,2]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"U.S. Food and Drug Administration Cytrellis Dermal Micro\u2010Coring SystemJuly 12 2023 https:\/\/www.accessdata.fda.gov\/cdrh_docs\/pdf20\/K202517.pdf."},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000003552"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000004547"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000003905"},{"key":"e_1_2_10_6_1","volume-title":"Presented at: ASDS Annual Meeting","author":"Waibel J. S.","year":"2023"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70323","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T05:30:43Z","timestamp":1755581443000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.70323"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":5,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1111\/jocd.70323"],"URL":"https:\/\/doi.org\/10.1111\/jocd.70323","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"2025-01-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70323"}}