{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T22:08:14Z","timestamp":1791842894163,"version":"4.3.4"},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T00:00:00Z","timestamp":1751932800000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hyperpigmentation and periorbital dark circles remain challenging dermatological concerns due to their multifactorial etiology, including vascular, pigmentary, and structural components. This study evaluates the efficacy of a novel multi\u2010action topical formulation designed to target hyperpigmentation and skin aging through a synergistic blend of active ingredients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To assess the objective and clinical effects of a dermatological composition containing niacinamide, arbutin, tranexamic acid, ubiquinone, a\n                      <jats:styled-content style=\"fixed-case\">DHEA<\/jats:styled-content>\n                      \u2010like component, curcuma oily extract, and marine exopolysaccharides on periorbital hyperpigmentation and skin quality.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Subjects with visible under\u2010eye dark circles applied the formulation twice daily over a treatment period of 6\u2009weeks. The evaluation included instrumental quantitative assessments of skin pigmentation along with standardized imaging. A separate safety study and cosmetic efficacy questionnaire of patient experience were completed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The formulation demonstrated statistically significant improvements in pigmentation intensity. The twice daily use of the under\u2010eye serum resulted in an average overall reduction in under\u2010eye hyperpigmentation of 47.94%, with no adverse effects observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This novel topical composition offers a safe and effective multi\u2010targeted approach for improving periorbital hyperpigmentation and promoting overall skin rejuvenation. The synergistic action of its active components supports its use in clinical and aesthetic dermatology for the treatment of dark circles and age\u2010related changes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70326","type":"journal-article","created":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T05:46:24Z","timestamp":1751953584000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Clinical Efficacy of a Novel Topical Formulation on Periorbital Dark Circles: An Objective Analysis"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5839-8566","authenticated-orcid":false,"given":"Robert Thomas","family":"Brady","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Addenbrooke's Hospital  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Shah\u2010Desai","sequence":"additional","affiliation":[{"name":"Perfect Eyes Ltd  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,8]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1473-2165.2007.00324.x"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0846.2007.00277.x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4RA13315C"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-2077.184046"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2018.30.5.522"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000002484"},{"issue":"7","key":"e_1_2_11_8_1","first-page":"725","article-title":"Novel Eye Cream Containing a Mixture of Human Growth Factors and Cytokines for Periorbital Skin Rejuvenation","volume":"6","author":"Lupo M. L.","year":"2007","journal-title":"Journal of Drugs in Dermatology"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13705"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12072"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.18203\/issn.2455-4529.IntJResDermatol20191001"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12480680"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20153520"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.16122"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2008.00522.x"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2002.04834.x"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.13717"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.16122"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.4103\/2277-9175.148292"},{"issue":"2","key":"e_1_2_11_20_1","first-page":"18","article-title":"Effectiveness and Safety of Topical Under\u2010Eye Serum in Patients With Periorbital Hyperpigmentation: An Open\u2010Label Single Arm Prospective Study","volume":"15","author":"Chandrashekar B. S.","year":"2022","journal-title":"Journal of Clinical and Aesthetic Dermatology"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000002484"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70326","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T05:30:36Z","timestamp":1755581436000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.70326"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":20,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1111\/jocd.70326"],"URL":"https:\/\/doi.org\/10.1111\/jocd.70326","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"2025-04-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70326"}}