{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T19:46:50Z","timestamp":1779392810096,"version":"3.53.1"},"reference-count":24,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T00:00:00Z","timestamp":1752537600000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173436"],"award-info":[{"award-number":["82173436"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82373499"],"award-info":[{"award-number":["82373499"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Despite numerous treatment modalities for striae distensae (SD), a definitive gold standard therapy remains unidentified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>This study aims to evaluate and compare the efficacy of injectable poly\u2010L\u2010lactic acid (PLLA) with a 1565\u2010nm non\u2010ablative fractional laser (NAFL) in treating SD located in the abdominal area.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>40 women with SD were randomly assigned to one of four treatment groups: (1) control, (2) PLLA, (3) 1565\u2010nm NAFL, and (4) a combination of PLLA and 1565\u2010nm NAFL. Participants, except those in the control group, underwent three treatment sessions at monthly intervals. Antera 3D imaging was used to collect data at baseline (T0) and 3\u2009months post\u2010treatment (T4). Collagen fibers were analyzed via immunohistochemical staining, while elastic fibers were assessed using picrosirius red and Masson staining at both T0 and T4.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall efficacy scores for the PLLA, 1565\u2010nm NAFL, and PLLA + 1565\u2010nm NAFL groups were 5.70\u2009\u00b1\u20091.25, 3.60\u2009\u00b1\u20092.12, and 6.70\u2009\u00b1\u20092.21, respectively. Post\u2010treatment evaluations demonstrated substantial decreases in SD volume from T0 to T4, with reductions of \u22121.96\u2009\u00b1\u20091.53 in the PLLA group, \u22120.70\u2009\u00b1\u20090.67 in the 1565\u2010nm NAFL group, and \u22121.48\u2009\u00b1\u20091.35 in the PLLA\u2009+\u20091565\u2010nm NAFL group. The combined and PLLA groups exhibited significant reductions in area compared to the 1565\u2010nm NAFL and control groups. Histological analysis confirmed the presence of PLLA particles in the treated area without inflammatory reactions 1\u2009month post\u2010final injection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>PLLA injections are more effective than 1565\u2010nm NAFL in SD treatment, enhancing collagen production without inducing inflammation in treated skin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial Registration<\/jats:title><jats:p><jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">Clinicaltrials.gov<\/jats:ext-link>: NCT05827913<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.70338","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T09:38:21Z","timestamp":1752572301000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical Efficacy Comparisons Between Poly\u2010L\u2010Lactic Acid Injections and Non\u2010Ablative 1565\u2010nm Fractional Laser for Treatment of Striae Distensae\u2014A Randomized Trial"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1824-3564","authenticated-orcid":false,"given":"Huanhuan","family":"Qu","sequence":"first","affiliation":[{"name":"Department of Dermatology, Xijing Hospital The Fourth Military Medical University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Xijing Hospital The Fourth Military Medical University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wuyan","family":"Xin","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Xijing Hospital The Fourth Military Medical University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiheng","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Xijing Hospital The Fourth Military Medical University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Jing","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Xijing Hospital The Fourth Military Medical University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Xijing Hospital The Fourth Military Medical University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Xijing Hospital The Fourth Military Medical University  Xi'an Shaanxi 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