{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T11:53:55Z","timestamp":1790855635092,"version":"4.1.0"},"reference-count":63,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T00:00:00Z","timestamp":1751587200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Oral supplementation with omega\u20103 polyunsaturated fatty acids (\u03c9\u20103 PUFAs) has shown beneficial effects in some dermatologic diseases (i.e., atopic dermatitis, acne, psoriasis, burns), but the actual effect of local application of \u03c9\u20103 PUFAs for improving skin health is still under investigation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>This paper systematically reviewed the current articles regarding the use of topical \u03c9\u20103 PUFAs in the treatment of skin diseases to evaluate its efficacy and safety.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The review was conducted according to Preferred Reporting Items for Systematic Reviews and Meta\u2010analysis (PRISMA) recommendations. Studies in which \u03c9\u20103 PUFAs were administered as oral treatments, those with a reduced or unknown \u03c9\u20103 PUFAs composition, and those using with skin fish grafts were excluded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In skin models of psoriasis, wounds, dermatitis, and melanoma, topical \u03c9\u20103 PUFAs showed an overall beneficial effect associated with the anti\u2010inflammatory properties of these compounds. Furthermore, none of the studies reported cases of skin irritation, cytotoxicity, or any adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The increasing number of studies conducted on topical treatments with \u03c9\u20103 PUFAs and the existing evidence suggest that \u03c9\u20103 PUFAs could be a promising option as an adjuvant or complementary treatment in managing several dermatological conditions. However, there is still a lack of consensus about the optimal dosage, molecules, or delivery methods of \u03c9\u20103 PUFAs; consequently, more clinical studies are needed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.70341","type":"journal-article","created":{"date-parts":[[2025,7,5]],"date-time":"2025-07-05T02:39:52Z","timestamp":1751683192000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Therapeutic Benefits of Topical Omega\u20103 Polyunsaturated Fatty Acids in Skin Diseases and Cosmetics: An Updated Systematic Review"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8522-4748","authenticated-orcid":false,"given":"Laura","family":"Mateu\u2010Arrom","sequence":"first","affiliation":[{"name":"Department of Dermatology, Hospital de la Santa Creu i Sant Pau, Institut d'Investigaci\u00f3 Biom\u00e8dica Sant Pau (IIB Sant Pau) Universitat Aut\u00f2noma de Barcelona (UAB)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3861-8071","authenticated-orcid":false,"given":"Ignasi","family":"Mora","sequence":"additional","affiliation":[{"name":"Brudy Technology, S.L.  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