{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T17:45:28Z","timestamp":1755798328587,"version":"3.44.0"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T00:00:00Z","timestamp":1752451200000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003787","name":"Natural Science Foundation of Hebei Province","doi-asserted-by":"publisher","award":["H2023209084"],"award-info":[{"award-number":["H2023209084"]}],"id":[{"id":"10.13039\/501100003787","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Vitiligo and freckles are both pigmentary disorders of the skin. The high prevalence of these conditions also places substantial strain on social healthcare systems. While vitiligo shows genetic predisposition, freckles exhibit autosomal dominant inheritance. Both conditions are closely linked to the immune system, potentially involving immune irregularities and autoimmune deficiencies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to investigate the correlation between vitiligo and freckles in relation to major histocompatibility complex (MHC) regions to better understand the genetic factors influencing these chronic pigmentation disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from 3315 vitiligo patients, 7168 healthy controls, 524 freckle patients, and 4280 healthy controls were collected. A genome\u2010wide association study (GWAS) utilizing the Infinium Global Screening Array\u201024 v2.0 BeadChip (GSA) and MHC region imputation was conducted, followed by meta\u2010analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Through stepwise conditional analysis, five single\u2010nucleotide polymorphisms (SNPs) associated with both vitiligo and freckles were identified. These genetic markers shed light on common susceptibility factors between the two diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The findings of this study provide insights into the genetic basis of vitiligo and freckles, suggesting potential associations and shared pathways. Understanding these genetic correlations can aid in disease diagnosis, prevention strategies, and further exploration of biological mechanisms underlying these pigmentation disorders.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.70342","type":"journal-article","created":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T12:10:56Z","timestamp":1752495056000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Genome\u2010Wide Meta\u2010Analysis Identifies Five Single\u2010Nucleotide Polymorphisms Associated With Both Vitiligo and Freckles in the Chinese Han Population"],"prefix":"10.1111","volume":"24","author":[{"given":"Jiayi","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Dermatology The First Affiliated Hospital of Anhui Medical University  Hefei China"},{"name":"Key Laboratory of Dermatology (Anhui Medical University), Ministry of Education  Hefei 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