{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T23:28:25Z","timestamp":1790206105446,"version":"4.1.0"},"reference-count":54,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T00:00:00Z","timestamp":1754352000000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Although bioactive compounds from single herbs are extensively explored in cosmetics, the synergistic potential of herbal combinations remains understudied. This study aimed to evaluate the stability of a combined extract of <jats:styled-content style=\"fixed-case\"><jats:italic>Panax ginseng<\/jats:italic><\/jats:styled-content>, <jats:italic>Ganoderma lucidum<\/jats:italic>, <jats:italic>Cordyceps militaris<\/jats:italic>, and several Asian plants (PGC), and its multifunctional efficacy for acne\u2010related skin dysfunction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>PGC was analyzed using high\u2010performance liquid chromatography (HPLC) for batch consistency and bioactive quantification. Network pharmacology and molecular docking were used to identify active components and targets and assess binding affinities, respectively. In\u00a0vitro assays were conducted to evaluate antibacterial activity, skin barrier repair, keratinocyte migration, reactive oxygen species (ROS) reduction, anti\u2010inflammatory effects, and inhibition of lipid accumulation. The safety was tested via cytotoxicity assessments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>HPLC analysis validated batch consistency and identified key bioactive constituents in PGC, including phenolic acids, flavonoids, and alkaloids. Integrated network pharmacology and molecular docking revealed multitarget mechanisms through the regulation of the IL\u201017\/TNF\/NF\u2010\u03baB axis pathway modulation. PGC exhibited potent antibacterial efficacy against acne\u2010associated pathogens (<jats:italic>Cutibacterium acne<\/jats:italic>, MIC\u2009=\u200925\u2009\u03bcg\/mL), restored skin barrier integrity (filaggrin, +235%; loricrin, +261%), and sodium dodecyl sulfate (SDS)\u2010induced damage (85%). Concurrently, PGC accelerated keratinocyte migration (40%), reduced ROS (45%) and abnormal lipid droplet content (60%), and attenuated inflammatory responses (40% nitric oxide (NO) inhibition) while maintaining biosafety (no cytotoxicity \u2264\u2009200\u2009\u03bcg\/mL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PGC exemplified the translational potential of herbal compatibility, offering a multitargets solution for acne management through integrating antibacterial, barrier\u2010repair, anti\u2010inflammatory actions, and several other effects. This study established a network pharmacology\u2010guided framework for developing evidence\u2010based multitargets cosmetics.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.70343","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T10:35:41Z","timestamp":1754390141000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Potential Cosmetic Applications of the Combined Extract of <i>Panax ginseng<\/i>, <i>Ganoderma lucidum<\/i>, <i>Cordyceps militaris<\/i>, and Several Asian Plants"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5949-8806","authenticated-orcid":false,"given":"Wenlong","family":"Wang","sequence":"first","affiliation":[{"name":"Lasur Cosmetics Co., Ltd.  Huzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Zhong","sequence":"additional","affiliation":[{"name":"Lasur Cosmetics Co., Ltd.  Huzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronghua","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Pharmacy Jiangxi University of Chinese Medicine  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shichun","family":"Zhao","sequence":"additional","affiliation":[{"name":"Lasur Cosmetics Co., Ltd.  Huzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianwen","family":"Wei","sequence":"additional","affiliation":[{"name":"Lasur Cosmetics Co., Ltd.  Huzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiwan","family":"Zheng","sequence":"additional","affiliation":[{"name":"Lasur Cosmetics Co., Ltd.  Huzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingyu","family":"Zhong","sequence":"additional","affiliation":[{"name":"Lasur Cosmetics Co., Ltd.  Huzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Shen","sequence":"additional","affiliation":[{"name":"Lasur Cosmetics Co., Ltd.  Huzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"He","sequence":"additional","affiliation":[{"name":"Lasur Cosmetics Co., Ltd.  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