{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T16:47:19Z","timestamp":1788799639440,"version":"build-2803163510"},"reference-count":13,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T00:00:00Z","timestamp":1752451200000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The selective photothermolysis of sebaceous follicles with topically applied gold nanoparticles, followed by light exposure, shows good efficacy for acne treatment. Methods such as sonophoresis or CO<jats:sub>2<\/jats:sub> fractional laser can help to deliver gold nanoparticles efficiently. Additionally, ethosomes are introduced to enhance the skin penetration of gold nanoparticles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>This study aimed to assess the effectiveness and safety of the combination of CO<jats:sub>2<\/jats:sub> fractional laser and gold photothermal therapy for acne.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patinents\/Methods<\/jats:title><jats:p>Twenty\u2010four patients with moderate to severe acne were involved. They were randomly divided into two groups: Group 1 received CO<jats:sub>2<\/jats:sub> fractional laser treatment followed by ethosome gold nanoparticle ampule application, while Group 2 applied the ampule with sonophoresis. After ampule application, all patients underwent long\u2010pulsed Nd:YAG laser treatment (1064\u2009nm wavelength, fluence 4.5\u2009J\/cm<jats:sup>2<\/jats:sup>, frequency 10\u2009Hz, pulse duration 0.3\u2009ms, and spot size 10\u2009mm). Clinical evaluation, biopsy, and blood tests for gold detection assessed the effectiveness and safety of the treatments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ethosome gold photothermal therapy demonstrated significant clinical and histological improvements in acne vulgaris among Asian patients, showing no serious adverse effects or systemic absorption of gold nanoparticles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients treated with CO<jats:sub>2<\/jats:sub> fractional laser pretreatment before ampule application showed reductions across all acne lesion types, including comedones, and experienced improvement in acne scars.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.70349","type":"journal-article","created":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T09:04:49Z","timestamp":1752483889000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effect of <scp>CO<sub>2<\/sub><\/scp> Fractional Laser PreTreatment in Photothermal Therapy Using Ethosome Gold Nanoparticles: A Preliminary Study"],"prefix":"10.1111","volume":"24","author":[{"given":"Dong Hye","family":"Suh","sequence":"first","affiliation":[{"name":"ArumdaunNara Dermatologic Clinic  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Jun","family":"Lee","sequence":"additional","affiliation":[{"name":"ArumdaunNara Dermatologic Clinic  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heesu","family":"Kim","sequence":"additional","affiliation":[{"name":"Yonseinew Dermatology and Laser Clinic  Incheon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kye Yong","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Pathology College of Medicine, Chung\u2010Ang University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju Young","family":"Jo","sequence":"additional","affiliation":[{"name":"Department of Dermatology Korea University Ansan Hospital  Ansan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su Ji","family":"Chae","sequence":"additional","affiliation":[{"name":"Department of Dermatology Korea University Ansan Hospital  Ansan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2136-4682","authenticated-orcid":false,"given":"Hwa Jung","family":"Ryu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Korea University Ansan Hospital  Ansan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2015.89"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.13799"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403\u2010024\u201002979\u20101"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103\u2010022\u201003645\u20106"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.14918"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1039\/d1tb01310f"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.36849\/jdd.1088"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23076"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103\u2010024\u201004124\u2010w"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2015.03.004"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1039\/d0bm01712d"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpha.2023.06.001"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2024.1426477"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70349","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T05:31:22Z","timestamp":1755581482000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.70349"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":13,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1111\/jocd.70349"],"URL":"https:\/\/doi.org\/10.1111\/jocd.70349","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"2025-03-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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