{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:13:51Z","timestamp":1787015631216,"version":"build-2736575974"},"reference-count":15,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,19]],"date-time":"2025-07-19T00:00:00Z","timestamp":1752883200000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Acne vulgaris is a common skin condition characterized by excessive sebum production, inflammation, and compromised skin barrier function. Effective treatments should target both lesion reduction and skin hydration while maintaining tolerability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to evaluate the efficacy and tolerability of a salicylic acid\u2013containing gel in reducing sebum levels, improving skin hydration, strengthening the skin barrier, and alleviating acne severity over 21\u2009days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A single\u2010center, prospective clinical trial was conducted on 42 participants (37 females, 5 males, mean age: 25.86\u2009\u00b1\u20096.69\u2009years) with mild\u2010to\u2010moderate acne (IGA grade 2\u20133) and oily or combination skin. Participants applied the gel twice daily for 21\u2009days. Sebum levels (Sebumeter SM815), trans\u2010epidermal water loss (TEWL, Tewameter TM Hex), and skin hydration (Corneometer CM825) were measured at multiple time points. Acne severity was assessed using the IGA scale, and self\u2010reported satisfaction surveys were collected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Following the follow\u2010up period, sebum levels decreased by 23.65% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), while skin hydration increased by 40.5% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). TEWL decreased by 49.26% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), indicating enhanced skin barrier function. The IGA score improved by 23.81% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), demonstrating a significant reduction in acne severity. All participants (100%) reported satisfaction with the product, with notable improvements in oil control, acne reduction, and skin texture. The gel was well tolerated, with only 5% of participants reporting mild, transient itching, which resolved without intervention.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The salicylic acid\u2013containing gel effectively reduces acne lesions, regulates sebum production, enhances skin hydration, and strengthens the skin barrier, making it a suitable option for acne\u2010prone and sensitive skin. These findings suggest that the gel provides a well\u2010balanced approach to acne treatment by addressing both clinical efficacy and user comfort.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70353","type":"journal-article","created":{"date-parts":[[2025,7,19]],"date-time":"2025-07-19T07:49:53Z","timestamp":1752911393000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Clinical Efficacy of a Salicylic Acid\u2013Containing Gel on Acne Management and Skin Barrier Function: A 21\u2010Day Prospective Study"],"prefix":"10.1111","volume":"24","author":[{"given":"Ye","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Dermatology Huashan Hospital Affiliated to Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjun","family":"Dan","sequence":"additional","affiliation":[{"name":"Department of Dermatology Huashan Hospital Affiliated to Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahong","family":"Yang","sequence":"additional","affiliation":[{"name":"L'Or\u00e9al Dermatological Beauty China, CeraVe  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"He","sequence":"additional","affiliation":[{"name":"L'Or\u00e9al China Research and Innovation Center  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Liu","sequence":"additional","affiliation":[{"name":"L'Or\u00e9al China Research and Innovation Center  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Yi","sequence":"additional","affiliation":[{"name":"L'Or\u00e9al China Research and Innovation Center  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Chen","sequence":"additional","affiliation":[{"name":"L'Or\u00e9al Dermatological Beauty China, CeraVe  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Yin","sequence":"additional","affiliation":[{"name":"L'Or\u00e9al Dermatological Beauty China, CeraVe  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weina","family":"Song","sequence":"additional","affiliation":[{"name":"L'Or\u00e9al Dermatological Beauty China, CeraVe  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueiqng","family":"Niu","sequence":"additional","affiliation":[{"name":"L'Or\u00e9al Dermatological Beauty China, CeraVe  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0213-2302","authenticated-orcid":false,"given":"Yijie","family":"Zheng","sequence":"additional","affiliation":[{"name":"L'Or\u00e9al Dermatological Beauty China, CeraVe  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfei","family":"Ai","sequence":"additional","affiliation":[{"name":"L'Or\u00e9al Dermatological Beauty China, CeraVe  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,19]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2023.12.017"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.17633"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300060519847367"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-4642(22)00314-5"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13934"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S84765"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25105302"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14016"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.15381"},{"issue":"1","key":"e_1_2_12_11_1","first-page":"80","article-title":"Cohort Using a Ceramides Containing Cleanser and Cream With Salicylic Acid for Dry, Flaking, and Scaling Skin Conditions","volume":"18","author":"Vender R. B.","year":"2019","journal-title":"Journal of Drugs in Dermatology"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S476004"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S377759"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.36849\/JDD.7142"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.15746"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.16238"}],"updated-by":[{"DOI":"10.1111\/jocd.70589","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:00:00Z","timestamp":1764892800000}}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70353","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T05:31:01Z","timestamp":1755581461000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.70353"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":15,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1111\/jocd.70353"],"URL":"https:\/\/doi.org\/10.1111\/jocd.70353","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"2025-03-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70353"}}