{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T01:20:28Z","timestamp":1787793628315,"version":"build-2784847793"},"reference-count":18,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T00:00:00Z","timestamp":1756080000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T00:00:00Z","timestamp":1756080000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Minoxidil and finasteride are currently the only FDA\u2010approved pharmacological treatments for androgenic alopecia (AGA) and female androgenic alopecia (FAGA). However, substantial improvement is observed in no more than 20% of patients in the medium term. To enhance clinical responses, nonpharmacological dietary supplementation is often utilized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>\n                      This study evaluated the efficacy of a novel dietary supplement, AGA\u2010P, which contains\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Serenoa repens<\/jats:italic>\n                      <\/jats:styled-content>\n                      extract,\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Cucurbita pepo<\/jats:italic>\n                      <\/jats:styled-content>\n                      extract, L\u2010Cystine, and Vitamin C, in a multicenter, randomized, assessor\u2010blinded, real\u2010life trial alongside pharmacological treatments. The objective was to determine whether dietary supplementation could improve the clinical efficacy of minoxidil and finasteride.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>A total of 225 subjects with AGA or FAGA (165 men, mean age 40\u2009\u00b1\u200914\u2009years, range 18\u201374) were enrolled after obtaining informed consent. Inclusion criteria included male subjects over 18\u2009years and postmenopausal women with mild to moderate AGA\/FAGA, eligible for dietary and\/or pharmacological treatment. Of these participants, 106 (24 women and 82 men) were assigned to receive pharmacological treatment plus dietary supplementation (one capsule daily; Group A), while 119 (36 women and 83 men) received drug treatment only (Group B). The pharmacological treatments consisted of topical minoxidil and oral finasteride in most cases. Treatment duration was 6\u2009months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The results indicated that oral supplementation significantly increased the clinical efficacy of pharmacological treatments for mild\u2010to\u2010severe AGA\/FAGA compared to drug treatment alone (great improvement: Group A 36.5% vs. Group B 25%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Oral supplementation of AGA\u2010P significantly increases the clinical efficacy of pharmacological treatments for mild\u2010to\u2010severe AGA\/FAGA (Study Registration: ISRCTN\u201019671217).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70388","type":"journal-article","created":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T12:35:07Z","timestamp":1756125307000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Impact of a Novel Dietary Supplement on Efficacy of Pharmacological Treatments for Androgenic Alopecia: A Real\u2010Life, Multicenter, Randomized, Assessor\u2010Blinded Trial on 225 Subjects"],"prefix":"10.1111","volume":"24","author":[{"given":"Massimo","family":"Milani","sequence":"first","affiliation":[{"name":"Medical Department Cantabria Labs Difa Cooper  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Alfano","sequence":"additional","affiliation":[{"name":"Medical Department Cantabria Labs Difa Cooper  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"The AGA\u2010P Real\u2010Life Study 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Trichology"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/oso\/9780195168655.003.0014"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jemermed.2003.04.007"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.124088"},{"issue":"1","key":"e_1_2_10_14_1","first-page":"27","article-title":"Oral Supplementation With l\u2010Cystine, Serenoa repens, Cucurbita Pepo, and Pygeum Africanum in Chronic Telogen Effluvium and Androgenetic Alopecia: A Double\u2010Blind, Placebo\u2010Controlled, Randomized Clinical Study","volume":"11","author":"Piquero\u2010Casals J.","year":"2025","journal-title":"Skin Appendage Disorders"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.4081\/aiua.2021.4.475"},{"key":"e_1_2_10_16_1","first-page":"1190","article-title":"A Review on Cucurbita pepo","volume":"9","author":"Ratnam N.","year":"2017","journal-title":"International Journal of Pharmacy and Pharmaceutical 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