{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T06:25:06Z","timestamp":1782887106064,"version":"3.54.5"},"reference-count":40,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T00:00:00Z","timestamp":1755475200000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Male pattern hair loss is the most common form of hair loss in men, occurring in specific patterns. Contributing factors include hormonal changes, stress, malnutrition, and insufficient blood microcirculation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>Topical applied dimethylglycine sodium salt (DMG\u2010Na) has been identified to increase skin microcirculation by activating endothelial nitric oxide synthase and inducing nitric oxide production. Given the importance of sufficient microcirculation on hair growth, the goal of this study was to evaluate the effectiveness of topically applied DMG\u2010Na in combination with caffeine against male pattern hair loss.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A 24\u2010week, double\u2010blind, randomized, placebo\u2010controlled trial was conducted on 154 men with male pattern hair loss, treated with a DMG\u2010Na and caffeine\u2010containing shampoo or the corresponding placebo. The primary efficacy parameter was the change in the number of hairs pulled via hair pull test from baseline to 6\u2009months of daily product application. Clinical efficacy was further evaluated via phototrichogram analysis on a subgroup of 30 subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The decreased number of hairs pulled during the hair pull test after 6\u2009months of active shampoo application was significantly higher compared to the placebo (\u22122.8\u2009\u00b1\u20091.6 vs. 0.6\u2009\u00b1\u20092.2; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), with no reported adverse events. Phototrichogram results showed an increase in the number of hairs, hair density, and percentage of anagen hairs after 6\u2009months of active shampoo usage (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The clinical efficacy of this novel DMG\u2010Na and caffeine\u2010containing shampoo demonstrates significant potential against male pattern hair loss, offering promising results without any undesirable side effects.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.70390","type":"journal-article","created":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T10:18:36Z","timestamp":1755512316000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Novel Approach Against Male Pattern Hair Loss With Topical Dimethylglycine Sodium Salt (<scp>DMG<\/scp>\u2010Na) and Caffeine: Efficacy of a 24\u2010Week, Double\u2010Blind, Randomized, Placebo\u2010Controlled Trial"],"prefix":"10.1111","volume":"24","author":[{"given":"Leonardo","family":"Celleno","sequence":"first","affiliation":[{"name":"Product Testing Department Eurofins Biopharma  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Bussoletti","sequence":"additional","affiliation":[{"name":"Synlab Med srl.  Firenze Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Vittoria","family":"Tolaini","sequence":"additional","affiliation":[{"name":"Product Testing Department Eurofins Biopharma  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Rossi","sequence":"additional","affiliation":[{"name":"Dermatology Clinic, Department of Clinical Internal. Anesthesiologic and Cardiovascular Sciences Sapienza University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3843-420X","authenticated-orcid":false,"given":"Lorenzo","family":"Ala","sequence":"additional","affiliation":[{"name":"Dermatology Clinic, Department of Clinical Internal. Anesthesiologic and Cardiovascular Sciences Sapienza University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7650-1969","authenticated-orcid":false,"given":"Maike","family":"Becker","sequence":"additional","affiliation":[{"name":"Dr. Kurt Wolff GmbH &amp; Co. KG  Bielefeld Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2407-2557","authenticated-orcid":false,"given":"J\u00f6rn Michael","family":"V\u00f6lker","sequence":"additional","affiliation":[{"name":"Dr. Kurt Wolff GmbH &amp; Co. KG  Bielefeld Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0890-1666","authenticated-orcid":false,"given":"Erik Schulze Zur","family":"Wiesche","sequence":"additional","affiliation":[{"name":"Dr. August Wolff GmbH &amp; Co. 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