{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T02:20:56Z","timestamp":1764642056715,"version":"3.46.0"},"reference-count":16,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T00:00:00Z","timestamp":1760313600000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,10]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Post\u2010acne depressed spots appear due to localized fat atrophy and disruption of the dermis. Surgical excision of acne spots is challenging; thus, novel management is required.<\/jats:p>\n <\/jats:sec>\n \n Aims<\/jats:title>\n The aim of this study is to compare the long\u2010term effects of conventional and ex\u00a0vivo expanded ASCs enriched fat for the treatment of post\u2010acne spots.<\/jats:p>\n <\/jats:sec>\n \n Patients\/Methods<\/jats:title>\n After informed consent, 40 patients having post\u2010acne spots on the face were recruited and, after explaining, placed in two groups depending upon their choice. In lipofilling\u2010only group (LF), adipose tissue was harvested, prepared, and injected intradermally and subdermally in the depressed spots. In ASC\u2010enriched lipofilling group (ASC\u2010LF), fat wa\u0253g\u02bb enriched with cultured ASCs before injection. Improvement of the contour was noted clinically after 1\u2009year. Differences in dermal thickness were confirmed histologically on punch biopsies. Evaluation of pictures was done by two consultant plastic surgeons blinded to the technique. Similarly, the satisfaction of patients was also noted.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Mean age of patients was 26.32 (\u00b13.34) and 72% of patients were females. Cheeks only were involved in 57% of cases while cheeks associated with involvement of lateral forehead in 29% of cases, nose in 11% of cases, and chin in 3% of cases. In ASC\u2010LF group, improvement in dermal thickness (1.2\u2009\u00b1\u20090.6\u2009mm) was higher compared to LF group (0.5\u2009\u00b1\u20090.3\u2009mm). The mean scores of patients and physician satisfaction were higher in ASC\u2010LF group.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n This novel strategy significantly improved the acne\u2010related contours by increasing dermal thickness.<\/jats:p>\n <\/jats:sec>\n \n Trial Registration<\/jats:title>\n \n www.clinicaltrials.gov<\/jats:ext-link>\n : NCT06135519\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jocd.70399","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T01:39:33Z","timestamp":1760405973000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Adipose Tissue\u2010Derived Stem Cells Enhance Dermogenesis of Post\u2010Acne Depressed Spots"],"prefix":"10.1111","volume":"24","author":[{"given":"Afzaal","family":"Bashir","sequence":"first","affiliation":[{"name":"Jinnah Hospital Lahore\/Allama Iqbal Medical College Lahore Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2038-4817","authenticated-orcid":false,"given":"Mahmood S.","family":"Choudhery","sequence":"additional","affiliation":[{"name":"Department of Human Genetics & Molecular Biology University of Health Sciences Lahore Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunniya","family":"Afzaal","sequence":"additional","affiliation":[{"name":"Shalamar Medical and Dental College Lahore Lahore Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salman","family":"Ali","sequence":"additional","affiliation":[{"name":"Punjab Rangers Teaching Hospital Lahore Lahore Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunaina","family":"Afzaal","sequence":"additional","affiliation":[{"name":"Punjab Rangers Teaching Hospital Lahore Lahore Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.04214.x"},{"issue":"9","key":"e_1_2_10_3_1","first-page":"27","article-title":"The Role of Inflammation in the Pathology of Acne","volume":"6","author":"Tanghetti E. A.","year":"2013","journal-title":"Journal of Clinical and Aesthetic Dermatology"},{"issue":"4","key":"e_1_2_10_4_1","first-page":"34","article-title":"Preventing and Treating Acne","volume":"31","author":"Mossman J.","year":"2006","journal-title":"US Pharmacist"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25053006"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.30568"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2025.01.006"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000005912"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000004367"},{"issue":"8","key":"e_1_2_10_10_1","article-title":"A Comparative Analysis of the Advances in Stem Cell Therapy in Plastic Surgery: A Systematic Review of Current Applications and Future Directions","volume":"16","author":"Meretsky C. 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