{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:13:54Z","timestamp":1760141634579,"version":"build-2065373602"},"reference-count":15,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T00:00:00Z","timestamp":1755820800000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,8]]},"abstract":"ABSTRACT<\/jats:title>Background<\/jats:title>\nLow\u2010dose oral isotretinoin is increasingly used off\u2010label for photoaging, with evidence of clinical and histologic skin improvement.<\/jats:styled-content>\n<\/jats:p><\/jats:sec>Objective<\/jats:title>\nTo review ocular risks associated with isotretinoin in aesthetic use and propose monitoring recommendations.<\/jats:styled-content>\n<\/jats:p><\/jats:sec>Methods<\/jats:title>\nA narrative review of clinical studies, observational data, and mechanistic reports addressing isotretinoin\u2010induced ocular effects was performed, integrating dermatologic and ophthalmologic perspectives.<\/jats:styled-content>\n<\/jats:p><\/jats:sec>Results<\/jats:title>\nReported adverse effects include dry eye disease, meibomian gland dysfunction, and, rarely, retinal alterations. Risk may be cumulative in long\u2010term or repeated cosmetic regimens.<\/jats:styled-content>\n<\/jats:p><\/jats:sec>Conclusion<\/jats:title>\nA risk\u2010adapted monitoring approach, emphasizing patient selection, informed consent, and interdisciplinary care, is recommended to balance cosmetic benefits with ocular safety.<\/jats:styled-content>\n<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.70401","type":"journal-article","created":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T11:13:48Z","timestamp":1755861228000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ocular Surveillance During Off\u2010Label Oral Isotretinoin for Photoaging: A Review of Risks and Monitoring Recommendations"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1083-9622","authenticated-orcid":false,"given":"Fabiano Nadson","family":"Magacho\u2010Vieira","sequence":"first","affiliation":[{"name":"Magacho Institute for Health Education Fortaleza Cear\u00e1 Brazil"},{"name":"Department of Clinical, Aesthetic and Surgical Dermatology Batista Memorial Hospital Fortaleza Cear\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0284-0359","authenticated-orcid":false,"given":"Gilmasa Daniele Rios","family":"Dias","sequence":"additional","affiliation":[{"name":"Magacho Institute for Health Education Fortaleza Cear\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,22]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468\u20103083.2008.02919.x"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806\u20104841.20153131"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12367"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-9740.2007.07145.x"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ad.2022.03.017"},{"issue":"4","key":"e_1_2_12_7_1","first-page":"22","article-title":"Updated Physician's Guide to the Off\u2010Label Uses of Oral Isotretinoin","volume":"7","author":"Nickle S. 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