{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T03:39:51Z","timestamp":1783568391281,"version":"3.55.0"},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T00:00:00Z","timestamp":1755216000000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The combined efficacy and durability of botulinum toxin A (BTX) and hyaluronic acid fillers (HA) for canthal wrinkles have not been thoroughly evaluated in randomized clinical trials.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>This study evaluated the efficacy, safety, and durability of the combined treatment protocol of onabotulinumtoxinA and Juvederm Volite VYC\u201012 (Skinvive) for moderate and severe canthal lines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This randomized double\u2010blinded split\u2010face trial included 25 women with periorbital dynamic wrinkles at severity levels II\u2013IV according to the Merz 5\u2010point scale. After bilateral onabotulinummtoxinA injections, the sides of the participants' faces were randomized to receive HA injections or a simulated injection. Assessed variables included electromyography activity (EMG), Merz 5\u2010point crow's feet scale, and FACE\u2010Q appraisal on crow's feet lines. Assessments were performed at baseline, 1, 2, 3, and 6\u2009months. For differences in EMG and satisfaction scores, the two\u2010way repeated measures ANOVA and Bonferroni's post hoc analyses were conducted. Wrinkle severity scores were analyzed with the Mann\u2013Whitney U test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Inter\u2010treatment comparisons revealed no significant differences between treatment protocols in all assessed periods for EMG (<jats:italic>p<\/jats:italic>\u2009=\u20090.86). For severity of canthal wrinkles, onabotulinumtoxinA + VYC\u201012 exhibited lower canthal wrinkle severity in rest and contracted positions after 3 (<jats:italic>p<\/jats:italic>\u2009=\u20090.04), and 3 (<jats:italic>p<\/jats:italic>\u2009=\u20090.007) and 6 (<jats:italic>p<\/jats:italic>\u2009=\u20090.001) months, respectively. Additionally, satisfaction with BTX\u2010HA treatment was significantly higher after 3\u2010month (<jats:italic>p<\/jats:italic>\u2009=\u20090.001) and 6\u2010month (<jats:italic>p<\/jats:italic>\u2009=\u20090.001) follow\u2010ups compared to BTX treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Higher improvements in canthal wrinkles could be enhanced by using onabotulinumtoxinA and VYC\u201012 in association as a treatment protocol.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.70403","type":"journal-article","created":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T08:44:57Z","timestamp":1755247497000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Efficacy and Durability of the Association of Botox and Skinvive in the Treatment of Moderate\/Severe Wrinkles in the Periorbital Region: A Randomized, Controlled, Double\u2010Blind, Split\u2010Face Clinical Study"],"prefix":"10.1111","volume":"24","author":[{"given":"Maria Luiza Boechat Borges","family":"Neves","sequence":"first","affiliation":[{"name":"Department of Dentistry Ing\u00e1 University Center  Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Thome","sequence":"additional","affiliation":[{"name":"Private Practice  Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvio Ventura","family":"da Silva Junior","sequence":"additional","affiliation":[{"name":"Department of Dentistry Ing\u00e1 University Center  Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thalita","family":"Machado","sequence":"additional","affiliation":[{"name":"Department of Dentistry Ing\u00e1 University Center  Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"S\u00e1nchez\u2010Ayala","sequence":"additional","affiliation":[{"name":"Department of Dentistry University of Ponta Grossa  Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana Barbosa","family":"C\u00e2mara\u2010Souza","sequence":"additional","affiliation":[{"name":"Department of Dentistry Ing\u00e1 University Center  Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0921-342X","authenticated-orcid":false,"given":"Giancarlo","family":"De la Torre Canales","sequence":"additional","affiliation":[{"name":"Department of Dentistry Ing\u00e1 University Center  Paran\u00e1 Brazil"},{"name":"Egas Moniz Center for Interdisciplinary Research (CiiEM) Egas Moniz School of Health and Science  Almada Portugal"},{"name":"Division of Oral Rehabilitation, Department of Dental Medicine Karolinska Institutet  Huddinge Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2020.1832189"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534\u2010200207000\u201000047"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjaa339"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina59020230"},{"key":"e_1_2_10_6_1","unstructured":"ISAPS \u201cInternational Survey on Esthetic\/Cosmetic Procedures Performed in 2023 \u201d(2024) accessed January 17 2025 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