{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:13:42Z","timestamp":1760141622975,"version":"build-2065373602"},"reference-count":17,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T00:00:00Z","timestamp":1755648000000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Laser resurfacing treatments have revolutionized dermatological procedures by improving skin texture, tone, and quality. Effective periprocedural care remains essential to reduce side effects, support healing, and optimize aesthetic outcomes. Hypochlorous acid (HOCl), a naturally occurring oxidant with anti\u2010inflammatory and antimicrobial properties, has demonstrated efficacy in promoting wound healing and minimizing scarring.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the use of stabilized HOCl mist in the periprocedural care of patients undergoing laser resurfacing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ten patients underwent treatment with UltraClear, CO2RE, and\/or GentleMax Pro laser devices. Stabilized HOCl mist was applied before and after the procedure, with continued application twice daily for 1\u2009week posttreatment. Follow\u2010up assessments at 1\u20133\u2009weeks and 1\u20133\u2009months post\u2010procedure included clinical photography, tolerability evaluation, and aesthetic outcome assessment. Outcomes measured included Clinician Erythema Assessment (CEA), 4\u2010point Edema Scale, Investigator Global Assessment of Pigmentation Scale (IPA), and Global Aesthetic Improvement Scale (GAIS). Statistical analysis was performed using the Friedman and Wilcoxon signed\u2010rank tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>HOCl mist was associated with accelerated recovery, including a noticeable reduction in erythema and pigmentation. Statistically significant improvements were observed in CEA (<jats:italic>p<\/jats:italic>\u2009=\u20090.007) and IPA (<jats:italic>p<\/jats:italic>\u2009=\u20090.012) scores, indicating reduced clinical severity and pigment alteration. Edema and GAIS scores showed no statistically significant change.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Stabilized HOCl mist is well\u2010tolerated and may significantly aid post\u2010procedural recovery by minimizing side effects and reducing discomfort. Results support the potential role of stabilized HOCl mist as a beneficial adjunct in post\u2010laser skincare, contributing to faster healing, reduced inflammation, and enhanced cosmetic results.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.70412","type":"journal-article","created":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T09:06:43Z","timestamp":1755680803000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Periprocedural Use of Hypochlorous Acid Mist for Improving Healing and Cosmesis of the Face After Laser"],"prefix":"10.1111","volume":"24","author":[{"given":"Marianna","family":"Blyumin\u2010Karasik","sequence":"first","affiliation":[{"name":"Precision Skin &amp; Body Institute  Davie Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3333-8563","authenticated-orcid":false,"given":"Jessica","family":"Colon","sequence":"additional","affiliation":[{"name":"Nova Southeastern University Dr. Kiran C. Patel College of Osteopathic Medicine  Davie Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Gaer","sequence":"additional","affiliation":[{"name":"Precision Skin &amp; Body Institute  Davie Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabella","family":"Vigil","sequence":"additional","affiliation":[{"name":"Precision Skin &amp; Body Institute  Davie Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvie","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Nova Southeastern University Dr. Kiran C. Patel College of Osteopathic Medicine  Davie Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordan","family":"Rosen","sequence":"additional","affiliation":[{"name":"Precision Skin &amp; Body Institute  Davie Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.16514"},{"key":"e_1_2_11_3_1","unstructured":"UltraClear Laser Skin Rejuvenation Solutions \u201cUltraClear\u201d (2024) https:\/\/ultraclearlaser.com\/."},{"key":"e_1_2_11_4_1","unstructured":"Candela (2020) https:\/\/marketing.candelamedical.com\/EMEA\u2010HQ\u2010CP\u20102020\u201012\u2010CO2RE\u2010LookBook_Registration.html?country\u2010language=uk."},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.16668"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/14764172.2017.1400166"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.36849\/JDD.8092"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.16712"},{"key":"e_1_2_11_9_1","article-title":"Hypochlorous Acid: Applications in Dermatology","author":"Natarelli N.","year":"2022","journal-title":"Journal of Integrative Dermatology"},{"issue":"10","key":"e_1_2_11_10_1","first-page":"909","article-title":"Hypochlorous Acid: A Blast From the Past","volume":"23","author":"Menta N.","year":"2024","journal-title":"Journal of Drugs in Dermatology"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12330"},{"issue":"11","key":"e_1_2_11_12_1","first-page":"36","article-title":"Status Report on Topical Hypochlorous Acid: Clinical Relevance of Specific Formulations, Potential Modes of Action, and Study Outcomes","volume":"11","author":"Del Rosso J. Q.","year":"2018","journal-title":"Journal of Clinical and Aesthetic Dermatology"},{"issue":"8","key":"e_1_2_11_13_1","first-page":"24","article-title":"Review of Post\u2010Laser\u2010Resurfacing Topical Agents for Improved Healing and Cosmesis","volume":"14","author":"Angra K.","year":"2021","journal-title":"Journal of Clinical and Aesthetic Dermatology"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.2340\/actadv.v102.1624"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13280"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.21743"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S395256"},{"issue":"2","key":"e_1_2_11_18_1","first-page":"15","article-title":"A Multi\u2010Center Trial Evaluating a Serum Comprised of Plant\u2010Based Adaptogens Targeting Skin Quality","volume":"17","author":"Draelos Z. D.","year":"2024","journal-title":"Journal of Clinical and Aesthetic Dermatology"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.70412","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T02:01:55Z","timestamp":1760061715000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.70412"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":17,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1111\/jocd.70412"],"URL":"https:\/\/doi.org\/10.1111\/jocd.70412","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"type":"print","value":"1473-2130"},{"type":"electronic","value":"1473-2165"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"2025-05-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70412"}}