{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T02:40:06Z","timestamp":1760064006155,"version":"build-2065373602"},"reference-count":43,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T00:00:00Z","timestamp":1755820800000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Post\u2010inflammatory hyperpigmentation is a common dermatologic complaint that affects different parts of the body. Axillary hyperpigmentation (AH) is a common dermatologic complaint, with no standard treatment. We aim to address the efficacy and safety of the studied treatment modalities for AH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic search was done using \u201caxillary\u201d and \u201chyperpigmentation\u201d\u2010related keywords\/MeSH terms through PubMed\/Medline, Scopus, Web of Science, and Embase.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ten studies on AH were categorized into topical treatments, light\/laser\u2010based therapies, and comparative approaches. Topical agents like niacinamide, desonide, sweet orange extract, <jats:styled-content style=\"fixed-case\"><jats:italic>Perilla frutescens<\/jats:italic><\/jats:styled-content> leaf extract, <jats:styled-content style=\"fixed-case\"><jats:italic>Cyperus rotundus<\/jats:italic><\/jats:styled-content> oil, glycolic acid, and novel serums demonstrated varying degrees of pigmentation reduction, with desonide and <jats:styled-content style=\"fixed-case\"><jats:italic>C. rotundus<\/jats:italic><\/jats:styled-content> oil showing significant effectiveness and minimal side effects. Q\u2010switched Nd:YAG laser was effective across three studies. Both Q\u2010switched Nd:YAG laser and intense pulsed light (IPL) modalities showed significant improvement with minimal adverse events; though pain was more reported with the laser. A comparative study found IPL superior to alpha\u2010hydroxy acid in skin lightening and texture improvement. One study on Curcuma aeruginosa was excluded due to its primary focus on hair growth reduction rather than pigmentation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The most frequently used laser in treating AH was QS Nd\u2010YAG without having any severe adverse effect. Various topical treatments including Niacinamide, desonide, HQ, AHA, and a few herbal extracts were shown to be effective for AH.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.70418","type":"journal-article","created":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T10:13:35Z","timestamp":1755857615000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Axillary Hyperpigmentation Treatment: A Systematic Review of the Literature"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4736-6803","authenticated-orcid":false,"given":"Seyed Mohammad","family":"Vahabi","sequence":"first","affiliation":[{"name":"Department of Dermatology, Razi Hospital, School of Medicine Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sajjad","family":"Sajjadi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Razi Hospital, School of Medicine Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8443-4591","authenticated-orcid":false,"given":"Yasamin","family":"Kalantari","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Razi Hospital, School of Medicine Tehran University of Medical Sciences  Tehran Iran"},{"name":"Department of Dermatology, Venerology and Allergology Charit\u00e9 Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4069-7289","authenticated-orcid":false,"given":"Elnaz","family":"Pourgholi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Razi Hospital, School of Medicine Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2683-3750","authenticated-orcid":false,"given":"Sama","family":"Heidari","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Razi Hospital, School of Medicine Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3026-2485","authenticated-orcid":false,"given":"Ifa","family":"Etesami","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Razi Hospital, School of Medicine Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2024.07.297"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-017-0333-6"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2005.05.007"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28124839"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12986"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.14747"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S385162"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.14432"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/12034754241265716"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.19566"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2494.2012.00729.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.36849\/JDD.2020.4623"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-2494.2006.00328.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S39246"},{"key":"e_1_2_9_17_1","unstructured":"P. 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