{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T01:20:19Z","timestamp":1787793619799,"version":"build-2784847793"},"reference-count":24,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T00:00:00Z","timestamp":1757894400000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100006483","name":"AbbVie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006483","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>HA\u2010CaHA is a hybrid injectable combining hyaluronic acid and calcium hydroxyapatite for dual\u2010mode facial soft tissue augmentation. HA\u2010CaHA\u2010L includes 0.3% lidocaine HCL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This prospective, open\u2010label study evaluated the effectiveness and safety of HA\u2010CaHA for treating midface volume deficit.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Adults rated Moderate to Severe on the Allergan Midface Volume Deficit Scale (MFVDS) received HA\u2010CaHA (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009110) or HA\u2010CaHA\u2010L (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200930) in the cheek (primary injection region) and jawline (optional) areas, with optional touch\u2010up 2\u2009weeks later. Follow\u2010up visits occurred at Months 1, 3, 6, 9, and 12. The primary endpoint was the MFVDS responder rate (\u2265\u20091\u2010grade improvement from baseline) at Month 1. Secondary endpoints were the Global Aesthetic Improvement Scale (GAIS) responder rates and change from baseline on FACE\u2010Q Satisfaction with Cheeks and Satisfaction with Facial Appearance. Exploratory endpoints were the Allergan Cheek Smoothness Scale (ACSS) scores and 3D photo\u2010based midface movement tracking. Safety was assessed throughout.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At Month 1, MFVDS responder rate was 82.8%, remaining high through Month 12. The GAIS responder rates were 98.5% (investigator\u2010rated) and 91.8% (participant\u2010rated) at Month 1, remaining high through Month 12. FACE\u2010Q scores improved 33.3 (Cheeks) and 23.8 (Facial Appearance) points at Month 1, remaining high through Month 12. ACSS scores peaked at Months 3 (73.7%) and 6 (69.2%), with corresponding skin movement changes. Most participants (95.7%) experienced mild or moderate ISRs. The most common treatment\u2010related AEs were injection site pain (11.4%), injection site mass (10.7%), and headache (7.1%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>HA\u2010CaHA and HA\u2010CaHA\u2010L are effective and well\u2010tolerated for midface soft tissue augmentation, lasting up to 1\u2009year.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70430","type":"journal-article","created":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T08:20:20Z","timestamp":1757924420000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A Prospective, Open\u2010Label, Post Marketing Study of the Safety and Effectiveness of a Hyaluronic Acid and Calcium Hydroxyapatite Hybrid Injectable"],"prefix":"10.1111","volume":"24","author":[{"given":"Alessandro","family":"Gritti","sequence":"first","affiliation":[{"name":"Dr. Alessandro Gritti Oral and Maxillofacial Surgery  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malka","family":"Salomon","sequence":"additional","affiliation":[{"name":"Allergan Aesthetics, an AbbVie Company  Lod Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lea","family":"Elmaleh","sequence":"additional","affiliation":[{"name":"Allergan Aesthetics, an AbbVie Company  Lod Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graeme","family":"Kerson","sequence":"additional","affiliation":[{"name":"Allergan Aesthetics, an AbbVie Company  Marlow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Schumacher","sequence":"additional","affiliation":[{"name":"Allergan Aesthetics, an AbbVie Company  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,15]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/ics.12779"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjaa339"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.asj.2005.09.012"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100041\u20101724122"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/dss.0000000000000536"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.15867"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000285109.34527.b9"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266\u2010021\u201002479\u2010x"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/gox.0000000000005055"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.15706"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/gox.0000000000005622"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/dsu.12343"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12938"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042728\u2010200306000\u201000006"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000436814.11462.94"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cps.2012.12.001"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/dss.0000000000003802"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266\u2010018\u20101149\u20103"},{"issue":"12","key":"e_1_2_11_20_1","first-page":"857","article-title":"Observations Are Always Ordinal; Measurements, However, Must Be Interval","volume":"70","author":"Wright B. 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