{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T01:20:19Z","timestamp":1787793619753,"version":"build-2784847793"},"reference-count":17,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Deoxycholic acid (DCA) injection is a noninvasive method for localized fat reduction, offering lower risks compared to invasive techniques. This study evaluates the safety and efficacy of DCA injections for reducing flank fat.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>We assessed the efficacy and safety of DCA injections for flank fat reduction over a 12\u2010week period using imaging, anthropometric data, Global Aesthetic Improvement Scale (GAIS) scoring, participant satisfaction, and standardized adverse event reporting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients\/Methods<\/jats:title>\n                    <jats:p>\n                      Adults aged 21\u201365\u2009years with mild to moderate flank fat (\u2265\u20092\u2009cm) received two sessions of 10\u2009mg\/mL DCA injections, 6\u2009weeks apart. Standardized ultrasound and caliper measurements were performed prior to each session. Injections were administered at 0.1\u20130.15\u2009mL per 1\u2009\u00d7\u20091\u2009cm\n                      <jats:sup>2<\/jats:sup>\n                      area, with a maximum of 2\u2009mL per flank per session, following standardized marking and injection protocols.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty participants (mean age 34.9\u2009years; 86.7% female) completed the study. By Week 12, 86.7% showed aesthetic improvement based on GAIS score, with significant reductions in waist circumference and fat thickness (measured using caliper and ultrasound;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The procedure was generally safe, with most adverse events being mild to moderate and limited to the injection site.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>DCA injections effectively reduced localized flank fat after two treatment sessions, resulting in significant aesthetic improvements. Adverse events were mostly mild and manageable, with no serious complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70436","type":"journal-article","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T11:20:16Z","timestamp":1756725616000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluating the Efficacy and Safety of Deoxycholic Acid Injection in Reduction of Flank Fat"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1746-6283","authenticated-orcid":false,"given":"Navid","family":"Namakizadeh Esfahani","sequence":"first","affiliation":[{"name":"Department of Dermatology, Razi Hospital Tehran University of Medical Sciences  Tehran Iran"},{"name":"Autoimmune Bullous Diseases Research Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faezeh","family":"Khorasanizadeh","sequence":"additional","affiliation":[{"name":"Advanced Diagnostic and Interventional Radiology Research Center (ADIR) Tehran University of Medical Sciences  Tehran Iran"},{"name":"Department of Radiology, Razi Hospital Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amirhoushang","family":"Ehsani","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Razi Hospital Tehran University of Medical Sciences  Tehran Iran"},{"name":"Autoimmune Bullous Diseases Research Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0571-5940","authenticated-orcid":false,"given":"Maryam","family":"Nasimi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Razi Hospital Tehran University of Medical Sciences  Tehran Iran"},{"name":"Autoimmune Bullous Diseases Research Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1890-1005","authenticated-orcid":false,"given":"Hamidreza","family":"Mahmoudi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Razi Hospital Tehran University of Medical Sciences  Tehran Iran"},{"name":"Autoimmune Bullous Diseases Research Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamidreza","family":"Kafi","sequence":"additional","affiliation":[{"name":"Medical Department Orchid Pharmed Company  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Araz","family":"Sabzvari","sequence":"additional","affiliation":[{"name":"CinnaGen Medical Biotechnology Research Center Alborz University of Medical Sciences  Karaj 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