{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T01:20:40Z","timestamp":1787793640116,"version":"build-2784847793"},"reference-count":35,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T00:00:00Z","timestamp":1757980800000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Photorejuvenation is commonly employed to improve skin appearance but frequently leads to transient irritation and temporary impairment of skin barrier function. Incorporating platinum (Pt)\u2010liposome technology along with soothing ingredients such as panthenol, dipotassium glycyrrhizate, madecassoside, and\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Portulaca oleracea<\/jats:italic>\n                      <\/jats:styled-content>\n                      extract is expected to offer enhanced reparative and anti\u2010inflammatory effects, helping to alleviate post\u2010procedural skin sensitivity and restore barrier integrity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study aimed to evaluate the efficacy of a Pt\u2010liposome\u2010based facial mask in promoting skin recovery and soothing irritation post\u2010photorejuvenation. Furthermore, the study assessed potential synergistic benefits from combining Pt\u2010liposomes with established soothing agents.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients\/Methods<\/jats:title>\n                    <jats:p>We initially assessed the reparative effects of Pt\u2010liposomes using a 3D epidermal skin model and normal human epidermal keratinocytes (NHEK), evaluating parameters such as stratum corneum thickness, cholesterol content, ceramide chain length, and inflammatory responses (IL\u20108 mRNA expression) following lipopolysaccharide (LPS) stimulation. A randomized, split\u2010face clinical trial involving 30 subjects who underwent photorejuvenation treatment was then conducted. Each participant applied the Pt\u2010liposome\u2010infused facial mask to one side of the face and a control product on the other side. Skin hydration, transepidermal water loss (TEWL), and erythema, tightness, dryness, and scaliness were assessed using objective instrumentation and subjective evaluations at baseline and various intervals up to 14\u2009days post\u2010treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In vitro testing showed that Pt\u2010liposomes significantly increased stratum corneum thickness, cholesterol levels, and ceramide chain length (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). Pt\u2010liposomes also reduced histamine\u2010induced calcium influx in NHEK cells (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). In LPS\u2010stimulated THP\u20101 cells, combined treatment with Pt\u2010liposomes and soothing agents resulted in a greater reduction in IL\u20108 mRNA expression compared to either component alone (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). Clinical measurements indicated that the application of the Pt\u2010liposome\u2010based facial mask significantly increased skin hydration and reduced TEWL compared to control (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) from Day 1 to Day 14. Subjective and dermatological evaluations showed statistically significant improvements in erythema, tightness, dryness, and scaliness on the treated side at all measured time points. No adverse reactions were reported.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The Pt\u2010liposome\u2010infused facial mask can effectively promote skin barrier repair, alleviate irritation, and enhance hydration following photorejuvenation. Its synergistic combination with soothing ingredients provides rapid relief from irritation and sustained therapeutic benefits, supporting its potential as a safe and effective option for post\u2010procedural skincare.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70452","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T02:31:02Z","timestamp":1758076262000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A Split\u2010Face Randomized Study on the Efficacy of a Platinum\u2010Liposome\u2010Based Facial Mask Containing Soothing Ingredients for Post\u2010Photorejuvenation Skin Recovery"],"prefix":"10.1111","volume":"24","author":[{"given":"Zhixin","family":"Du","sequence":"first","affiliation":[{"name":"Hua An Tang Biotech Group Co., Ltd.  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Ren","sequence":"additional","affiliation":[{"name":"Hua An Tang Biotech Group Co., Ltd.  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Liang","sequence":"additional","affiliation":[{"name":"Hua An Tang Biotech Group Co., Ltd.  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjie","family":"Lu","sequence":"additional","affiliation":[{"name":"Hua An Tang Biotech Group Co., Ltd.  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hua An Tang Biotech Group Co., Ltd.  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanghao","family":"Li","sequence":"additional","affiliation":[{"name":"Hua An Tang Biotech Group Co., Ltd.  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