{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T06:36:16Z","timestamp":1789022176717,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T00:00:00Z","timestamp":1764288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This study aimed to investigate the relationship between early\u2010onset androgenetic alopecia (AGA) and the prevalence of insulin resistance (IR) and metabolic syndrome (MetS) in young adult males.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 200 males aged 18 to 35\u2009years were enrolled in this case\u2013control study, including 100 patients with early\u2010onset AGA and 100 age\u2010 and body mass index\u2010matched controls. Clinical staging was performed using the Hamilton\u2013Norwood classification, and all participants underwent standardized physical and biochemical evaluation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The prevalence of insulin resistance (HOMA\u2010IR \u2265\u20092.7) was significantly higher in the AGA group compared to the control group (18% vs. 4%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003). Similarly, MetS was more common among AGA patients (21% vs. 9%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.011). Fasting insulin levels, triglyceride concentrations, and HOMA\u2010IR scores were all significantly elevated in the AGA group, while HDL\u2010C levels were comparable between groups. Waist circumference was also significantly greater in the AGA group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.026). When stratified by AGA severity, the frequency of IR progressively increased with increasing Hamilton\u2013Norwood stages. No significant differences were observed in fasting glucose or blood pressure categories. Although individual MetS components were similar, cumulative clustering of risk factors appeared to be associated with a significantly higher MetS frequency among patients with AGA.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Early\u2010onset AGA in men may serve as a visible clinical indicator of underlying metabolic disturbances, particularly IR. Routine metabolic screening may be advisable in young men presenting with advanced AGA stage.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70458","type":"journal-article","created":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T09:38:36Z","timestamp":1764322716000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Increased Prevalence of Insulin Resistance and Metabolic Syndrome in Men With Early\u2010Onset Androgenetic Alopecia: A Case\u2013Control Study"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4447-8319","authenticated-orcid":false,"given":"Orkun","family":"Erden","sequence":"first","affiliation":[{"name":"Department of Dermatology Atlas University Faculty of Medicine  Istanbul Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4687-0522","authenticated-orcid":false,"given":"Ahu","family":"Yorulmaz","sequence":"additional","affiliation":[{"name":"Department of Dermatology Ankara Bilkent City Hospital  Ankara Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basak","family":"Yalcin","sequence":"additional","affiliation":[{"name":"Department of Dermatology Private Clinic  Ankara 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