{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T21:23:50Z","timestamp":1776201830652,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T00:00:00Z","timestamp":1758499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Seborrheic dermatitis (SD) is a chronic inflammatory skin disease. Artemisinin and its derivatives have been applied in the treatment of various skin diseases, but they have not yet been used in the treatment of SD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To evaluate the therapeutic effect and anti\u2010inflammatory effect of 0.063% artemether shampoo on SD through a guinea pig model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      Fifty SD\u2010induced guinea pigs were randomized into control, ketoconazole (2%), matrix, and artemether (0.063%) groups (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200910\/group). Treatments were applied twice weekly for 2\u2009weeks. Erythema and scaling were scored pre\u2010\/posttreatment. Lesional IL\u20101\u03b2, IL\u20108, IL\u201017, NF\u2010\u03baB, and histamine H1 levels were quantified via immunohistochemistry.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Artemether group demonstrated lower scores versus control and matrix group (both\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), comparable to ketoconazole group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05). Artemether group reduced IL\u20101\u03b2, IL\u20108, NF\u2010\u03baB, and histamine H1 vs. control group(\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), with IL\u20108 suppression exceeding ketoconazole and matrix group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). No intergroup differences in IL\u201017 were observed (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The 0.063% artemether shampoo has comparable clinical efficacy to the 2% ketoconazole shampoo in the treatment of SD, and may exhibit stronger anti\u2010inflammatory effects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.70461","type":"journal-article","created":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T12:09:21Z","timestamp":1758542961000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Anti\u2010Inflammatory Efficacy of a Functional Shampoo Mixed With 0.063% Artemether for Seborrheic Dermatitis"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-4411-2055","authenticated-orcid":false,"given":"Qin","family":"Pei","sequence":"first","affiliation":[{"name":"Department of Dermatology Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei\u2010Lin","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mao\u2010Lin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Dermatology Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian\u2010Biao","family":"Fei","sequence":"additional","affiliation":[{"name":"Department of Dermatology Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai\u2010Hong","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Dermatology Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital  Shanghai 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